Publications2017-12-19T22:50:06+00:00

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Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues

March 14, 2017

Chepelev NL, Gagné R, Maynor T, Hobbs CA, Kuo B, Yauk CL, Recio L. 2017. Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 1830)

Customizing the Connectivity Map Approach for Functional Evaluation in Toxicogenomics Studies

March 13, 2017

Karmaus AL, Kothiya P, Watford S, Thomas RS, Martin MT. 2017. Customizing the Connectivity Map Approach for Functional Evaluation in Toxicogenomics Studies. Presented at SOT Annual Meeting on March 13, 2017 (Abstract #1374)

Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks

March 13, 2017

Hobbs CA, Sinha N, Chepelev N, Gagné R, Christy N, Yauk CL, Recio L. 2017. Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks. Presented at SOT Annual Meeting on March 13, 2017 (Abstract #1344)

Integration of metabolic activation w TGx signature to classify genotoxic vs nongenotoxic chemicals

October 6, 2015

J.K. Buick, I. Moffat, A. Williams, C.D. Swartz, L. Recio, D. R. Hyduke, H.H. Li, A.J. Fornace Jr, J. Aubrecht, C.L. Yauk. (2015) Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ Mol Mutagen 56:520–534. doi.org/10.1002/em.21940. PMID: 25733247

A predictive TGx signature to classify genotoxic vs non-genotoxic chemicals in human TK6 cells

October 6, 2015

Andrew Williams, Julie K. Buick, Ivy Moffat, Carol D. Swartz, Leslie Recio, Daniel R. Hyduke, Heng-Hong Li, Albert J. Fornace Jr., Jiri Aubrecht, Carole L. Yauk. (2015) A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells. Data in Brief. doi:10.1016/j.dib.2015.08.013

Impact of Genomics Platform & Statistics on Transcriptional BMD & Selection of Chemical PoD

October 6, 2015

Webster AF, Chepelev N, Gagné R, Kuo B, Recio L, Williams A, Yauk CL. (2015) Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD). PLoS One. Aug 27;10(8):e0136764. doi: 10.1371/journal.pone.0136764. PMID: 26313361

TGx & traditional approaches to inform MoA and PoD in health risk assessment of benzo[a]pyrene

October 6, 2015

Moffat I, Chepelev NL, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Williams A, Halappanavar S, Malik AI, Luijten M, Aubrecht J, Hyduke DR, Fornace AJ Jr, Swartz CD, Recio L, Yauk CL. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol. 45(1):1-43. doi: 10.3109/10408444.2014.973934. Review. PMID: 25605026

BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA in mouse

October 6, 2015

Webster AF, Williams A, Recio L, Yauk CL. (2014) Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323:26-31. doi: 10.1016/j.tox.2014.06.002. PMID: 24910943

Mining the archives: a cross-platform analysis of gene expression profiles in archival FFPE tissue

October 6, 2015

Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE. (2015) Mining the archives: a cross-platform analysis of gene expression profiles in archival formalin-fixed paraffin-embedded (FFPE) tissue. Toxicol Sci. [Epub ahead of print] PMID: 26361796

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis

April 7, 2015

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.Hall JR, Messenger ZJ, Tam HW, Phillips SL, Recio L, Smart RC. Cell Death Dis. 2015 Mar 19

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice

April 7, 2015

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan. Recio L, Phillips SL, Maynor T, Waters M , Jackson AF, Yauk CL. Toxicol Sci. 2013 Oct;135(2):369-79.

Gene Expression of Mesothelioma in Vinylidene Chloride-exposed F344/N Rats Reveal Immune Dysfunction

February 20, 2015

Blackshear PE1, Pandiri AR2, Nagai H3, Bhusari S3, Hong HH3, Ton TV3, Clayton NP3, Wyde M4, Shockley KR5, Peddada SD5, Gerrish KE6, Sills RC3, Hoenerhoff MJ7. Toxicol Pathol. 2014 Jun 23

Case study on the utility of hepatic gene expression profiling in the risk assessment of furan.

October 15, 2014

Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL. 2014. Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. Toxicol Appl Pharmacol. 274(1):63-77.

Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform.

April 29, 2013

Jackson AF, Williams A, Moffat I, Phillips SL, Recio L, Waters MD, Lambert IB, Yauk CL. 2013. Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform. J Pharmacol Toxicol Methods. S1056-8719(13)00211-6.