Names of ILS employees are shown in boldface font:
Comparative inhalation toxicity of ethyltoluene isomers in rats and mice
January 29, 2018
Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey &
Daniel L. Morgan
Ninety-day toxicity and single-dose toxicokinetics study of AGIQ in Sprague-Dawley rats
September 27, 2016
Nyska A, Hayashi S, Koyanagi M, Davis J, Jokinen M, Ramot Y, Maronpot R. 2016. Ninety-day toxicity and single-dose toxicokinetics study of alphaglycosyl isoquercitrin in Sprague-Dawley rats. Food and Chemical Toxicology. 2016 Sep 27. pii: S0278-6915(16)30346-5.
Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents
July 1, 2016
Morgan D, Jokinen M, Johnson C, Price H, Gwinn W, Bousquet R, Flake G. 2016. Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents: 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione. Toxicologic Pathology. 2016 Jul;44(5):763-83. doi: 10.1177/0192623316638962.
Enhanced stability of TTP mRNA protects mice against immune-mediated inflammatory pathologies
February 8, 2016
Patial S, Curtis AD, Lai WS, Stumpo DJ, Hill GD, Flake GP, Mannie MD, Blackshear PJ. Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. Proc Natl Acad Sci U S A. 2016 Feb 1. pii: 201519906.
Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis
December 14, 2015
Ippolito DL, AbdulHameed MD, Tawa GJ, Baer CE, Permenter MG, McDyre BC, Dennis WE, Boyle MH, Hobbs CA, Streicker MA , Snowden BS, Lewis JA, Wallqvist A, Stallings JD.Gene expression patterns associated with histopathology in toxic liver fibrosis. Toxicol Sci. 2015 Sep 22. pii: kfv214.
Utilizing Whole Slide Images for Pathology Peer Review and Working Groups
November 13, 2015
Malarkey DE, Willson GA, Willson CJ, Adams ET, Olson GR, Witt WM, Elmore SA, Hardisty JF, Boyle MC, Crabbs TA, Miller RA. (2015) Utilizing Whole Slide Images for Pathology Peer Review and Working Groups. Toxicol Pathol. 2015 Oct 27. pii: 0192623315605933
IHC Expression of Cyclin D1, Cytokeratin 20, & Uroplakin III Induced by o-Nitroanisole
October 6, 2015
Cynthia J. Willson, Gordon P. Flake, Robert C. Sills, Grace E. Kissling, and Mark F. Cesta. (2015) Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats. Veterinary Pathology, first published on August 28, 2015 as doi:10.1177/0300985815603432
BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA in mouse
October 6, 2015
Webster AF, Williams A, Recio L, Yauk CL. (2014) Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323:26-31. doi: 10.1016/j.tox.2014.06.002. PMID: 24910943
Mining the archives: a cross-platform analysis of gene expression profiles in archival FFPE tissue
October 6, 2015
Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE. (2015) Mining the archives: a cross-platform analysis of gene expression profiles in archival formalin-fixed paraffin-embedded (FFPE) tissue. Toxicol Sci. [Epub ahead of print] PMID: 26361796
Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in rats
September 21, 2015
Robert R. Maronpot, Mihoko Koyanagi, Jeffrey Davis, Leslie Recio, Dean Marbury, Molly Boyle & Shim-Mo Hayashi. (2015) Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in Sprague Dawley rats. Food Additives & Contaminants: Part A (2015).
Histopathological and Immunohistochemical Characterization of Cell Leisons in Stomach of Rats
July 24, 2015
Janardhan KS , Rebolloso Y, Hurlburt G, Olson D, Lyght O, Clayton NP, Gruebbel M, Picut C, Shackelford C, Herbert RA. (2015) Histopathological and Immunohistochemical Characterization of Methly Eugenol-induced Nonneoplastic and Neoplastic Neuroendocrine Cell Lesions in Glandular Stomach of Rats. Toxicologic Pathology. 2015 Jul.
Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats
July 15, 2015
Willson, C.J., Herbert, R.A., Cline, J.M. (2015) Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats. Toxicologic Pathology. 2015 Jul. 7
Methyl Isobutyl Ketone Exposure-Related Increases in Specific Measures of Nephropathy in Male Rats
April 1, 2015
Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. Toxicology. 2015 Mar 19
Gene Expression of Mesothelioma in Vinylidene Chloride-exposed F344/N Rats Reveal Immune Dysfunction
February 20, 2015
Blackshear PE1, Pandiri AR2, Nagai H3, Bhusari S3, Hong HH3, Ton TV3, Clayton NP3, Wyde M4, Shockley KR5, Peddada SD5, Gerrish KE6, Sills RC3, Hoenerhoff MJ7. Toxicol Pathol. 2014 Jun 23
Case study on the utility of hepatic gene expression profiling in the risk assessment of furan.
October 15, 2014
Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL. 2014. Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. Toxicol Appl Pharmacol. 274(1):63-77.
Relative potency for altered humoral immunity induced by polybrominated & polychlorinated dioxins.
October 15, 2014
Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D. 2014. Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. Toxicol Sci. 139(2):488-500.
BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA changes.
October 15, 2014
Webster AF, Williams A, Recio L, Yauk CL. 2014. Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323C:26-31.
Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course
June 3, 2013
Boyle MC, Boyle MH, and the Sixth Rodent Pathology Course Committee. 2013. Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course. Vet. Pathol. 50(3): 563-8.
Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in mouse
July 19, 2012
Burns, KA, Rodriguez, KF, Hewitt, SC, Janardhan, KS, Young, SL, Korach, KS. Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in a mouse model. Endocrinology Epub June 14 2012.
Proliferative and Non-proliferative Lesions of the Rat and Mouse Central & Peripheral Nervous System
July 19, 2012
Kaufmann,W., Bolon, B., Bradley, A., Butt, M., Czasch, S., Garman, R.H., George, C., Groters S., Krinke, G., Little, P., McKay, J., Narama, I., Rao, D., Shibutani, M., and Sills, R.A. (2012) Proliferative and Non-proliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems. Toxicol Pathol.40: 87S-157S.
Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors
July 19, 2012
Morgan DL, Jokinen MP, Price HC, Gwinn WM, Palmer SM, Flake GP. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: Implication for bronchiolitis obliterans in humans. Toxicol. Pathol. 40:448-465, 2012.
Morphologic aspects of rodent cardiotoxicity in a restrospective evaluation of National Toxicology P
July 19, 2012
Jokinen MP, Lieuallen WG, Boyle MC, Johnson CL, Malarkey DE, Nyska A. Morphologic aspects of rodent cardiotoxicity in a restrospective evaluation of National Toxicology Program studies. Toxicol. Pathol. 39:850-860, 2011.
Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol
July 19, 2012
Michael C. Boyle, Torrie A. Crabbs, Michael E. Wyde, J. Todd Painter, Georgette D. Hill, David E. Malarkey, Warren G. Lieuallen, and Abraham Nyska(2012) Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol via Oral Gavage. Toxicologic Pathology, Vol. 40, No. 4, 561–576 (2012).
Disseminiated Histoplasmosis with Concurrent Oral Candidiasis in an Eclectus Parrot
October 19, 2011
Quist EM,Belcher C,Levine G,Johnson M,Heatley JJ,Kiupel M, Giri D. 2011. Disseminated Histoplasmosis with Concurrent Oral Candidiasis in an Electus Parrot (Eclectus Roratus). Avian Pathol. 40(3):339.
Cerebral and Renal Phaeohyphomycosis in a Dog Infected with Bipolaris Species
October 19, 2011
Giri DK,Sims WP,Sura R,Cooper JJ,Gavrilov BK,Mansell J. 2011. Cerebral and Renal Phaeohhyphomycosis in a Dog Infected with Bipolaris Species. Vet Pathol. 48(3):754-7.
Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish
October 17, 2011
Hobbie KR,DeAngelo AB,George MH,Law JM. 2011. Neoplastic and Nonneoplastic Liver Lesion Induced by Dimethylnitrosamine in Japanes Medaka Fish. Vet. Pathol. Online. DOI: 10.1177/0300985811409443.
Liver Toxicity and Carcinogenicity in f344/n Rats and b6cf1 Mice Exposed to Kava Kava
September 22, 2011
Behl M,Nyska A,Chhabra RS,Travlos G,Fomby LM,Sparrow BR,Hejtmancik MR,Chan PC. 2011. Liver Toxicity and Carcinogenicity in f344/n Rats and b6c3f1 Mice Exposed to Kava Kava. Food and Chemical Toxicology. In press for publication in November 2011.
Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies
September 18, 2011
Rao, D, Little, PB, Malarkey, D.E, Herbert, RA, Sills, RC. 2011. Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies: A Modified Approach. Toxicologic Pathology 39: 463-470.
Toxicity Study of Green Tea Extract in Rats and Mice
December 1, 2010
Chan PC, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A. 2010. Fourteen week Toxicity Study of Green Tea Extract in Rats and Mice. Toxicol. Pathol. 38(7): 1070-1084.