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Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace

October 14, 2019

Wan-Chi Lin, Kymberly M. Gowdy, Jennifer H. Madenspacher, Rachel L. Zemans, Kazuko Yamamoto, Miranda R. Lyons-Cohen, Hideki Nakano, Kyathanahalli Janardhan, Carmen J. Williams, Donald N. Cook, Joseph P. Mizgerd, and Michael B. Fessler

National Toxicology Program Position Statement on Informed (“Nonblinded”) Analysis in Toxicologic Pathology Evaluation

September 20, 2019

Robert C. Sills, Mark F. Cesta, Cynthia J. Willson, Amy E. Brix, Brian R. Berridge

Looking Forward: Cutting-Edge Technologies and Skills for Pathologists in the Future

September 17, 2019

Kyathanahalli S. Janardhan, Rebecca Kohnken, Oliver C. Turner, Channabasavaiah B. Gurumurthy, Ramesh C. Kovi

Comparative Incidences and Biological Outcomes for Thymoma in Various Rat Strains in National Toxicology Program Studies.

August 13, 2019

Moore RR, Nagai H, Miller RA, Hardisty JF, Allison N, Shockley KR, Malarkey DE

Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis

July 31, 2019

Pengcheng Chen, Shang Wang, Kyathanahalli S. Janardhan, Rachel L. Zemans, Wenhai Deng, Peer Karmaus, Shudan Shen, Mary Sunday, Loretta G. Que, Michael B. Fessler and Xiao-Ping Zhong

ERBB2 Regulates MED24 during Cancer Progression in Mice with Pten and Smad4 Deletion in the Pulmonary Epithelium

July 31, 2019

Jian Liu, Tianyuan Wang, Cynthia J. Willson, Kyathanahalli S. Janardhan, San-Pin Wu, Jian-Liang Li and Francesco J. DeMayo

Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program

July 31, 2019

Kyathanahalli S. Janardhan, Priyanka Venkannagari, Heather Jensen, Mark J. Hoenerhoff, Ronald A. Herbert, David E. Malarkey, Robert C. Sills, Arun R. Pandiri

JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression

July 31, 2019

Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis & Francesco J. DeMayo

Comparative inhalation toxicity of ethyltoluene isomers in rats and mice

January 29, 2018

Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey &
Daniel L. Morgan

Ninety-day toxicity and single-dose toxicokinetics study of AGIQ in Sprague-Dawley rats

September 27, 2016

Nyska A, Hayashi S, Koyanagi M, Davis J, Jokinen M, Ramot Y, Maronpot R. 2016. Ninety-day toxicity and single-dose toxicokinetics study of alphaglycosyl isoquercitrin in Sprague-Dawley rats. Food and Chemical Toxicology. 2016 Sep 27. pii: S0278-6915(16)30346-5.

Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents

July 1, 2016

Morgan D, Jokinen M, Johnson C, Price H, Gwinn W, Bousquet R, Flake G. 2016. Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents: 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione. Toxicologic Pathology. 2016 Jul;44(5):763-83. doi: 10.1177/0192623316638962.

Enhanced stability of TTP mRNA protects mice against immune-mediated inflammatory pathologies

February 8, 2016

Patial S, Curtis AD, Lai WS, Stumpo DJ, Hill GD, Flake GP, Mannie MD, Blackshear PJ. Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. Proc Natl Acad Sci U S A. 2016 Feb 1. pii: 201519906.

Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis

December 14, 2015

Ippolito DL, AbdulHameed MD, Tawa GJ, Baer CE, Permenter MG, McDyre BC, Dennis WE, Boyle MH, Hobbs CA, Streicker MA , Snowden BS, Lewis JA, Wallqvist A, Stallings JD.Gene expression patterns associated with histopathology in toxic liver fibrosis. Toxicol Sci. 2015 Sep 22. pii: kfv214.

Utilizing Whole Slide Images for Pathology Peer Review and Working Groups

November 13, 2015

Malarkey DE, Willson GA, Willson CJ, Adams ET, Olson GR, Witt WM, Elmore SA, Hardisty JF, Boyle MC, Crabbs TA, Miller RA. (2015) Utilizing Whole Slide Images for Pathology Peer Review and Working Groups. Toxicol Pathol. 2015 Oct 27. pii: 0192623315605933

IHC Expression of Cyclin D1, Cytokeratin 20, & Uroplakin III Induced by o-Nitroanisole

October 6, 2015

Cynthia J. Willson, Gordon P. Flake, Robert C. Sills, Grace E. Kissling, and Mark F. Cesta. (2015) Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats. Veterinary Pathology, first published on August 28, 2015 as doi:10.1177/0300985815603432

BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA in mouse

October 6, 2015

Webster AF, Williams A, Recio L, Yauk CL. (2014) Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323:26-31. doi: 10.1016/j.tox.2014.06.002. PMID: 24910943

Mining the archives: a cross-platform analysis of gene expression profiles in archival FFPE tissue

October 6, 2015

Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE. (2015) Mining the archives: a cross-platform analysis of gene expression profiles in archival formalin-fixed paraffin-embedded (FFPE) tissue. Toxicol Sci. [Epub ahead of print] PMID: 26361796

Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in rats

September 21, 2015

Robert R. Maronpot, Mihoko Koyanagi, Jeffrey Davis, Leslie Recio, Dean Marbury, Molly Boyle & Shim-Mo Hayashi. (2015) Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in Sprague Dawley rats. Food Additives & Contaminants: Part A (2015).

Histopathological and Immunohistochemical Characterization of Cell Leisons in Stomach of Rats

July 24, 2015

Janardhan KS , Rebolloso Y, Hurlburt G, Olson D, Lyght O, Clayton NP, Gruebbel M, Picut C, Shackelford C, Herbert RA. (2015) Histopathological and Immunohistochemical Characterization of Methly Eugenol-induced Nonneoplastic and Neoplastic Neuroendocrine Cell Lesions in Glandular Stomach of Rats. Toxicologic Pathology. 2015 Jul.

Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats

July 15, 2015

Willson, C.J., Herbert, R.A., Cline, J.M. (2015) Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats. Toxicologic Pathology. 2015 Jul. 7

Methyl Isobutyl Ketone Exposure-Related Increases in Specific Measures of Nephropathy in Male Rats

April 1, 2015

Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. Toxicology. 2015 Mar 19

Gene Expression of Mesothelioma in Vinylidene Chloride-exposed F344/N Rats Reveal Immune Dysfunction

February 20, 2015

Blackshear PE1, Pandiri AR2, Nagai H3, Bhusari S3, Hong HH3, Ton TV3, Clayton NP3, Wyde M4, Shockley KR5, Peddada SD5, Gerrish KE6, Sills RC3, Hoenerhoff MJ7. Toxicol Pathol. 2014 Jun 23

Case study on the utility of hepatic gene expression profiling in the risk assessment of furan.

October 15, 2014

Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL. 2014. Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. Toxicol Appl Pharmacol. 274(1):63-77.

Relative potency for altered humoral immunity induced by polybrominated & polychlorinated dioxins.

October 15, 2014

Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D. 2014. Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. Toxicol Sci. 139(2):488-500.

BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA changes.

October 15, 2014

Webster AF, Williams A, Recio L, Yauk CL. 2014. Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323C:26-31.

Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course

June 3, 2013

Boyle MC, Boyle MH, and the Sixth Rodent Pathology Course Committee. 2013. Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course. Vet. Pathol. 50(3): 563-8.

Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in mouse

July 19, 2012

Burns, KA, Rodriguez, KF, Hewitt, SC, Janardhan, KS, Young, SL, Korach, KS. Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in a mouse model. Endocrinology Epub June 14 2012.

Proliferative and Non-proliferative Lesions of the Rat and Mouse Central & Peripheral Nervous System

July 19, 2012

Kaufmann,W., Bolon, B., Bradley, A., Butt, M., Czasch, S., Garman, R.H., George, C., Groters S., Krinke, G., Little, P., McKay, J., Narama, I., Rao, D., Shibutani, M., and Sills, R.A. (2012) Proliferative and Non-proliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems. Toxicol Pathol.40: 87S-157S.

Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors

July 19, 2012

Morgan DL, Jokinen MP, Price HC, Gwinn WM, Palmer SM, Flake GP. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: Implication for bronchiolitis obliterans in humans. Toxicol. Pathol. 40:448-465, 2012.

Morphologic aspects of rodent cardiotoxicity in a restrospective evaluation of National Toxicology P

July 19, 2012

Jokinen MP, Lieuallen WG, Boyle MC, Johnson CL, Malarkey DE, Nyska A. Morphologic aspects of rodent cardiotoxicity in a restrospective evaluation of National Toxicology Program studies. Toxicol. Pathol. 39:850-860, 2011.

Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol

July 19, 2012

Michael C. Boyle, Torrie A. Crabbs, Michael E. Wyde, J. Todd Painter, Georgette D. Hill, David E. Malarkey, Warren G. Lieuallen, and Abraham Nyska(2012) Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol via Oral Gavage. Toxicologic Pathology, Vol. 40, No. 4, 561–576 (2012).

Disseminiated Histoplasmosis with Concurrent Oral Candidiasis in an Eclectus Parrot

October 19, 2011

Quist EM,Belcher C,Levine G,Johnson M,Heatley JJ,Kiupel M, Giri D. 2011. Disseminated Histoplasmosis with Concurrent Oral Candidiasis in an Electus Parrot (Eclectus Roratus). Avian Pathol. 40(3):339.

Cerebral and Renal Phaeohyphomycosis in a Dog Infected with Bipolaris Species

October 19, 2011

Giri DK,Sims WP,Sura R,Cooper JJ,Gavrilov BK,Mansell J. 2011. Cerebral and Renal Phaeohhyphomycosis in a Dog Infected with Bipolaris Species. Vet Pathol. 48(3):754-7.

Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish

October 17, 2011

Hobbie KR,DeAngelo AB,George MH,Law JM. 2011. Neoplastic and Nonneoplastic Liver Lesion Induced by Dimethylnitrosamine in Japanes Medaka Fish. Vet. Pathol. Online. DOI: 10.1177/0300985811409443.

Liver Toxicity and Carcinogenicity in f344/n Rats and b6cf1 Mice Exposed to Kava Kava

September 22, 2011

Behl M,Nyska A,Chhabra RS,Travlos G,Fomby LM,Sparrow BR,Hejtmancik MR,Chan PC. 2011. Liver Toxicity and Carcinogenicity in f344/n Rats and b6c3f1 Mice Exposed to Kava Kava. Food and Chemical Toxicology. In press for publication in November 2011.

Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies

September 18, 2011

Rao, D, Little, PB, Malarkey, D.E, Herbert, RA, Sills, RC. 2011. Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies: A Modified Approach. Toxicologic Pathology 39: 463-470.

Toxicity Study of Green Tea Extract in Rats and Mice

December 1, 2010

Chan PC, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A. 2010. Fourteen week Toxicity Study of Green Tea Extract in Rats and Mice. Toxicol. Pathol. 38(7): 1070-1084.