Publications 2017-12-19T22:50:06+00:00

Publications

Services

Names of ILS employees are shown in boldface font:

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin

June 4, 2018

Cheryl Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Robert Maronpot, Leslie Recio, Shim-mo Hayashi

Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential

February 26, 2018

Cheryl A. Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-mo Hayashi

Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential

February 23, 2018

Cheryl A. Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Sawako Kasamoto, Robert Maronpot, Leslie Recio, Shim-mo Hayashi

In Vitro to In Vivo extrapolation for high throughput prioritization and decision making

January 3, 2018

 

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes N, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. 2017. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicology In Vitro. 2017 Dec 5. doi:10.1016/j.tiv.2017.11.016

Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues

March 14, 2017

Chepelev NL, Gagné R, Maynor T, Hobbs CA, Kuo B, Yauk CL, Recio L. 2017. Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 1830)

Ninety-day toxicity and single-dose toxicokinetics study of AGIQ in Sprague-Dawley rats

September 27, 2016

Nyska A, Hayashi S, Koyanagi M, Davis J, Jokinen M, Ramot Y, Maronpot R. 2016. Ninety-day toxicity and single-dose toxicokinetics study of alphaglycosyl isoquercitrin in Sprague-Dawley rats. Food and Chemical Toxicology. 2016 Sep 27. pii: S0278-6915(16)30346-5.

Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents

July 1, 2016

Morgan D, Jokinen M, Johnson C, Price H, Gwinn W, Bousquet R, Flake G. 2016. Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents: 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione. Toxicologic Pathology. 2016 Jul;44(5):763-83. doi: 10.1177/0192623316638962.

Differential genotoxicity of acrylamide in the MN and Pig-a assays in F344 rats and B6C3F1 mice

June 23, 2016

Hobbs CA, Davis J, Shepard K, Chepelev N, Friedman M, Marroni D, Recio L. 2016. Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice. Mutagenesis. 2016 Jun 23. pii: gew028

Utilizing Whole Slide Images for Pathology Peer Review and Working Groups

November 13, 2015

Malarkey DE, Willson GA, Willson CJ, Adams ET, Olson GR, Witt WM, Elmore SA, Hardisty JF, Boyle MC, Crabbs TA, Miller RA. (2015) Utilizing Whole Slide Images for Pathology Peer Review and Working Groups. Toxicol Pathol. 2015 Oct 27. pii: 0192623315605933

IHC Expression of Cyclin D1, Cytokeratin 20, & Uroplakin III Induced by o-Nitroanisole

October 6, 2015

Cynthia J. Willson, Gordon P. Flake, Robert C. Sills, Grace E. Kissling, and Mark F. Cesta. (2015) Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats. Veterinary Pathology, first published on August 28, 2015 as doi:10.1177/0300985815603432

TGx & traditional approaches to inform MoA and PoD in health risk assessment of benzo[a]pyrene

October 6, 2015

Moffat I, Chepelev NL, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Williams A, Halappanavar S, Malik AI, Luijten M, Aubrecht J, Hyduke DR, Fornace AJ Jr, Swartz CD, Recio L, Yauk CL. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol. 45(1):1-43. doi: 10.3109/10408444.2014.973934. Review. PMID: 25605026

BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA in mouse

October 6, 2015

Webster AF, Williams A, Recio L, Yauk CL. (2014) Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323:26-31. doi: 10.1016/j.tox.2014.06.002. PMID: 24910943

Mining the archives: a cross-platform analysis of gene expression profiles in archival FFPE tissue

October 6, 2015

Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE. (2015) Mining the archives: a cross-platform analysis of gene expression profiles in archival formalin-fixed paraffin-embedded (FFPE) tissue. Toxicol Sci. [Epub ahead of print] PMID: 26361796

Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in rats

September 21, 2015

Robert R. Maronpot, Mihoko Koyanagi, Jeffrey Davis, Leslie Recio, Dean Marbury, Molly Boyle & Shim-Mo Hayashi. (2015) Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in Sprague Dawley rats. Food Additives & Contaminants: Part A (2015).

Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin

August 3, 2015

Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L , Koyanagi M, Hayashi SM. (2015) Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin. Food and Chemical Toxicology 83 (2015) 283-292.

Histopathological and Immunohistochemical Characterization of Cell Leisons in Stomach of Rats

July 24, 2015

Janardhan KS , Rebolloso Y, Hurlburt G, Olson D, Lyght O, Clayton NP, Gruebbel M, Picut C, Shackelford C, Herbert RA. (2015) Histopathological and Immunohistochemical Characterization of Methly Eugenol-induced Nonneoplastic and Neoplastic Neuroendocrine Cell Lesions in Glandular Stomach of Rats. Toxicologic Pathology. 2015 Jul.

Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats

July 15, 2015

Willson, C.J., Herbert, R.A., Cline, J.M. (2015) Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats. Toxicologic Pathology. 2015 Jul. 7

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice

April 7, 2015

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan. Recio L, Phillips SL, Maynor T, Waters M , Jackson AF, Yauk CL. Toxicol Sci. 2013 Oct;135(2):369-79.

Comet assay evaluation of six chemicals of known genotoxic potential in rats

April 1, 2015

Hobbs CA L. Recio L, Streicker M, Boyle M , Tanaka J, Shiga A, Witt KL. Genet. Toxicol. Environ. Mutagen. (2015).

Methyl Isobutyl Ketone Exposure-Related Increases in Specific Measures of Nephropathy in Male Rats

April 1, 2015

Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. Toxicology. 2015 Mar 19

Gene Expression of Mesothelioma in Vinylidene Chloride-exposed F344/N Rats Reveal Immune Dysfunction

February 20, 2015

Blackshear PE1, Pandiri AR2, Nagai H3, Bhusari S3, Hong HH3, Ton TV3, Clayton NP3, Wyde M4, Shockley KR5, Peddada SD5, Gerrish KE6, Sills RC3, Hoenerhoff MJ7. Toxicol Pathol. 2014 Jun 23

Case study on the utility of hepatic gene expression profiling in the risk assessment of furan.

October 15, 2014

Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL. 2014. Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. Toxicol Appl Pharmacol. 274(1):63-77.

BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA changes.

October 15, 2014

Webster AF, Williams A, Recio L, Yauk CL. 2014. Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323C:26-31.

Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform.

April 29, 2013

Jackson AF, Williams A, Moffat I, Phillips SL, Recio L, Waters MD, Lambert IB, Yauk CL. 2013. Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform. J Pharmacol Toxicol Methods. S1056-8719(13)00211-6.

Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghatti

December 12, 2012

Maronpot, R., Davis, J., Moser, G., Giri, D., Hayashi, S. 2012. Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghatti. Food and Chemical Toxicology, 51: 215-224.

Proliferative and Non-proliferative Lesions of the Rat and Mouse Central & Peripheral Nervous System

July 19, 2012

Kaufmann,W., Bolon, B., Bradley, A., Butt, M., Czasch, S., Garman, R.H., George, C., Groters S., Krinke, G., Little, P., McKay, J., Narama, I., Rao, D., Shibutani, M., and Sills, R.A. (2012) Proliferative and Non-proliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems. Toxicol Pathol.40: 87S-157S.

Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors

July 19, 2012

Morgan DL, Jokinen MP, Price HC, Gwinn WM, Palmer SM, Flake GP. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: Implication for bronchiolitis obliterans in humans. Toxicol. Pathol. 40:448-465, 2012.

Comparison Comet Assay Dose-Response Ethyl Methanesulfonate Freshly Prepared Vs Cryoprepared Tissues

July 18, 2012

Recio, L., Kissling, G.E., Hobbs, C.A., and Witt, K.L. (2012) Comparison of Comet Assay Dose-Response for Ethyl Methanesulfonate Using Freshly Prepared Versus Cryopreserved Tissues. Environmental and Molecular Mutagenesis 53, 101-113. DOI: 10.1002/em.20694.

Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti

June 18, 2012

Hobbs, C.A., Swartz, C., Maronpot, R., Davis, J., Recio, L., and Hayashi, S. (2012) Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti. Food and Chemical Toxicology 50, 854-860. DOI: 10.1016/j.fct.2011.11.021.

Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats

June 18, 2012

Hobbs, C.A., Chhabra, R.S., Recio, L., Streicker, M. and Witt, K.L. (2012) Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats. Environmental and Molecular Mutagenesis 53, 227-238. DOI: 10.1002/em.21680

Therapeutic Ultrasound as a Potential Male Contraceptive

March 23, 2012

Tsuruta JK, Dayton PA, Gallippi CM, O’Rand MG, Streicker MA, Gessner, RC, Gregory TS, Silva E JR, Hamil, KG, Moser GJ, Sokai, DC. 2012. Therapeutic Ultrasound as a Potential Male Contraceptive: Power, Frequency and Temperature Required to Deplete Rat Testes of Meiotic Cells and Epididymides of Sperm Determined Using Commercially Available System. Reproductive Biology and Endocrinology 10:7.

15-Day Intact Male Rat Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical

March 23, 2012

Becker RA, Bergfelt, DR, Borghoff S, Davis JP, Hamby BT, O’Connor JC, Kaplan AM, Sloan CS, Tyl, RW, Wade M, Marty MS. 2012. Interlaboratory Study Comparison of the 15-Day Intact Adult Male Rat Screening Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical. Birth Defects Research (Part B). (95):63-78.

Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti

December 21, 2011

Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L, and Hayashi S. 2011. Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti. Food and Chemical Toxicology DOI:10.1016/j.fct.2011.11.021.

Comet Assay Dose-Response for Ethyl Methanesulfonate Using Freshly Prepared Vs. Cryopreserved Tissue

November 26, 2011

Recio L, Kissling GE, Hobbs CA, and Witt KL, 2011. Comparison of Comet Assay Dose-Response for Ethyl Methansulfonate Using Freshly Prepared Versus Cryopreserved Tissues. Environmental and Molecular Mutagenesis (in press).

Liver Toxicity and Carcinogenicity in f344/n Rats and b6cf1 Mice Exposed to Kava Kava

September 22, 2011

Behl M,Nyska A,Chhabra RS,Travlos G,Fomby LM,Sparrow BR,Hejtmancik MR,Chan PC. 2011. Liver Toxicity and Carcinogenicity in f344/n Rats and b6c3f1 Mice Exposed to Kava Kava. Food and Chemical Toxicology. In press for publication in November 2011.

Assessment of a Regulated AAV2 Gene Transfer Vector After Murine Submandibular Glands Delivery

September 21, 2011

Zheng C,Voutetakis A,Goldstein B,Afione S,Rivera V,Clackson T,Wenk M,Boyle M,Nyska A,Chiorini J,Vallant M,Irwin R,Baum B. 2011. Assessment of the Safety and Biodistribution of a Regulated AAV2 Gene Transfer Vector After Delivery to Murine Submandibular Glands. Toxicological Sciences.

Effects of Atrazine on Steroidgenesis in Rat Granulosa and H295R Adrenal Cortical Carcinoma Cells

September 20, 2011

Tinfo NS,Hotchkiss MG,Buckalew AR,Zorrilla LM,Cooper RL,Laws SC. 2011. Understanding the Effects of Atrazine on Steriodogenesis in Rat Granulosa and H295 Adrenal Cortical Carcinoma Cells.Reprod. Toxicol. 31(2):184-93

Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies

September 18, 2011

Rao, D, Little, PB, Malarkey, D.E, Herbert, RA, Sills, RC. 2011. Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies: A Modified Approach. Toxicologic Pathology 39: 463-470.

Toxicity Study of Green Tea Extract in Rats and Mice

December 1, 2010

Chan PC, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A. 2010. Fourteen week Toxicity Study of Green Tea Extract in Rats and Mice. Toxicol. Pathol. 38(7): 1070-1084.

Characterizing and Predicting Carcinogenicity and Mode of Action

April 24, 2010

Waters M, Jackson MA, and Lea IA. 2010. Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods. Mutat Res 705: 184-200.

Dose-Response of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay

April 1, 2010

Recio L, Hobbs CA, Caspary W, Witt KL. 2010. Dose-Response Assessment of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay Protocol. Toxicol Sciences 35(2): 149-162.

No Biomarkers of Genetic Damage or Pathological Changes in Male Rats Administered Ritalin

January 1, 2010

Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. 2010. No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ Mol Mutagen 51(1): 80-88.