Publications 2017-12-19T22:50:06+00:00

Publications

Services

Names of ILS employees are shown in boldface font:

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

June 11, 2018

Debabrata Mahapatra, Jill A. Franzosa, Kyle Roell, Melaine Agnes Kuenemann, Keith A. Houck, David M. Reif, Denis Fourches & Seth W. Kullman

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin

June 4, 2018

Cheryl Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Robert Maronpot, Leslie Recio, Shim-mo Hayashi

Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential

February 26, 2018

Cheryl A. Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-mo Hayashi

In Vitro to In Vivo extrapolation for high throughput prioritization and decision making

January 3, 2018

 

Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes N, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. 2017. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicology In Vitro. 2017 Dec 5. doi:10.1016/j.tiv.2017.11.016

In Vitro Micronucleus and CometChip with Metabolically Competent HepaRG Cells

March 14, 2017

 

Swartz, CD, Winters, J, Owens, K, Yauk, CL, Buick, J, Ngo, L, Engelward, B, and Recio, L. 2017. In Vitro Micronucleus® and CometChip with Metabolically Competent HepaRG™ Cells. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 2267)

Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks

March 13, 2017

Hobbs CA, Sinha N, Chepelev N, Gagné R, Christy N, Yauk CL, Recio L. 2017. Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks. Presented at SOT Annual Meeting on March 13, 2017 (Abstract #1344)

Genotoxicity assessment of the flavouring agent, perillaldehyde

September 1, 2016

Hobbs C, Taylor S, Beevers C, Lloyd M, Bowen R, Lillford L, Maronpot R, Hayashi S. 2016. Genotoxicity assessment of the flavouring agent, perillaldehyde. Food and Chemical Toxicology. 2016 Sep 1;97:232-242. doi: 10.1016/j.fct.2016.08.029.

Integration of metabolic activation w TGx signature to classify genotoxic vs nongenotoxic chemicals

October 6, 2015

J.K. Buick, I. Moffat, A. Williams, C.D. Swartz, L. Recio, D. R. Hyduke, H.H. Li, A.J. Fornace Jr, J. Aubrecht, C.L. Yauk. (2015) Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ Mol Mutagen 56:520–534. doi.org/10.1002/em.21940. PMID: 25733247

A predictive TGx signature to classify genotoxic vs non-genotoxic chemicals in human TK6 cells

October 6, 2015

Andrew Williams, Julie K. Buick, Ivy Moffat, Carol D. Swartz, Leslie Recio, Daniel R. Hyduke, Heng-Hong Li, Albert J. Fornace Jr., Jiri Aubrecht, Carole L. Yauk. (2015) A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells. Data in Brief. doi:10.1016/j.dib.2015.08.013

Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin

August 3, 2015

Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L , Koyanagi M, Hayashi SM. (2015) Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin. Food and Chemical Toxicology 83 (2015) 283-292.

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay

June 1, 2015

Uno, Y., Kojima, H., Omori, T., Corvi, R., Honma, M., Schechtman, L.M., Tice, R.R., Beevers, C., De Boeck, M., Burlinson, B., Hobbs, C.A., Kitamoto, S., Kraynak, A.R., McNamee, J., Nakagawa, Y., Pant, K., Plappert-Helbig, U., Priestley, C., Takasawa, H., Wada, K., Wirnitzer, U., Asano, N., Escobar, P., Lovell, D., Morita, T., Nakajim, M., Ohno, Y., Hayashi, M. (2015) JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutation Research. 2015 Apr. 29

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis

April 7, 2015

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.Hall JR, Messenger ZJ, Tam HW, Phillips SL, Recio L, Smart RC. Cell Death Dis. 2015 Mar 19

Cytotoxicity of naphthalene toward cells from target and non-target organs in vitro.

October 15, 2014

Kedderis GL, Shepard KG, Recio. L. 2014. Cytotoxicity of naphthalene toward cells from target and non-target organs in vitro. Chem Biol Interact. 209:85-95.

Biomarkers of Exposure and Effect in Human Lymphoblastoid TK6 Cells Following [13C2]-Acetaldehyde Ex

April 29, 2013

Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, and Swenberg JA. 2013. Biomarkers of Exposure and Effect in Human Lymphoblastoid TK6 Cells Following [13C2]-Acetaldehyde Exposure. Toxicol Sci. 133(1): 1-12. Editor’s Highlight

Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti

June 18, 2012

Hobbs, C.A., Swartz, C., Maronpot, R., Davis, J., Recio, L., and Hayashi, S. (2012) Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti. Food and Chemical Toxicology 50, 854-860. DOI: 10.1016/j.fct.2011.11.021.

Assessment of Naphthalene-Induced Genotoxicity & Gluathione Detoxication in Human TK6 Lymphoblasts

March 26, 2012

Recio L, Shepard KG, Hernandez, LG, Kedderis GL. 2012. Dose-Response Assessment of Naphthalene-Induced Genotoxicity and Glutahione Detoxication in Human TK6 Lymphoblasts. Toxicol. Sci. 126(2):405-412.

Effects of Atrazine on Steroidgenesis in Rat Granulosa and H295R Adrenal Cortical Carcinoma Cells

September 20, 2011

Tinfo NS,Hotchkiss MG,Buckalew AR,Zorrilla LM,Cooper RL,Laws SC. 2011. Understanding the Effects of Atrazine on Steriodogenesis in Rat Granulosa and H295 Adrenal Cortical Carcinoma Cells.Reprod. Toxicol. 31(2):184-93

Genetic Toxicology in the 21st Century: Reflections and Future Directions

April 28, 2011

Mahadevan B, Snyder R, Waters M, Benz RD, Kemper RA, Tice RR and Richard AM. 2011. Genetic Toxicology in the 21st Century: Reflections and Future Directions. Environ. Mol. Mutagen. 52.

Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation

March 16, 2011

Hill GD, Moore AB, Kissling GE, Flagler ND, Ney E, Cline JM, Dixon D. 2011. Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation in the Myometrium of Ovariectomized Macaques. Toxicol. Pathol. 39(3): 508-515.

Characterizing and Predicting Carcinogenicity and Mode of Action

April 24, 2010

Waters M, Jackson MA, and Lea IA. 2010. Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods. Mutat Res 705: 184-200.