Publications 2017-12-19T22:50:06+00:00

Publications

Services

Names of ILS employees are shown in boldface font:

Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin

June 4, 2018

Cheryl Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Robert Maronpot, Leslie Recio, Shim-mo Hayashi

Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice

May 14, 2018

 

J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, A. Brix

Role of pathology peer review in interpretation of the comet assay

May 11, 2018

R. R. Maronpot, Cheryl A. Hobbs, Shim-mo Hayashi

Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells

April 25, 2018

Stephanie L. Smith‐Roe, Carol D. Swartz, Kim G. Shepard, Steven M. Bryce, Stephen D. Dertinger, Suramya Waidyanatha, Grace E. Kissling, Scott S. Auerbach, Kristine L. Witt, E. Zeiger

Transcriptional profiling of male CD-1 mouse lungs and harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors

February 26, 2018

Nikolai L. Chepelev⁠a, Rémi Gagné⁠, Timothy Maynor⁠, Byron Kuo⁠, Cheryl A. Hobbs⁠, Leslie Recio⁠, Carole L. Yauk⁠

Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential

February 26, 2018

Cheryl A. Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-mo Hayashi

Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential

February 23, 2018

Cheryl A. Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Sawako Kasamoto, Robert Maronpot, Leslie Recio, Shim-mo Hayashi

Impact of Acrylamide on Calcium Signaling and Cytoskeletal Filaments in Testes From F344 Rat.

March 16, 2017

 

Leslie Recio, Marvin Friedman, Dennis Marroni, Timothy Maynor, Nikolai Chepelev

In Vitro Micronucleus and CometChip with Metabolically Competent HepaRG Cells

March 14, 2017

 

Swartz, CD, Winters, J, Owens, K, Yauk, CL, Buick, J, Ngo, L, Engelward, B, and Recio, L. 2017. In Vitro Micronucleus® and CometChip with Metabolically Competent HepaRG™ Cells. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 2267)

Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues

March 14, 2017

Chepelev NL, Gagné R, Maynor T, Hobbs CA, Kuo B, Yauk CL, Recio L. 2017. Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 1830)

Genotoxicity assessment of the flavouring agent, perillaldehyde

September 1, 2016

Hobbs C, Taylor S, Beevers C, Lloyd M, Bowen R, Lillford L, Maronpot R, Hayashi S. 2016. Genotoxicity assessment of the flavouring agent, perillaldehyde. Food and Chemical Toxicology. 2016 Sep 1;97:232-242. doi: 10.1016/j.fct.2016.08.029.

Differential genotoxicity of acrylamide in the MN and Pig-a assays in F344 rats and B6C3F1 mice

June 23, 2016

Hobbs CA, Davis J, Shepard K, Chepelev N, Friedman M, Marroni D, Recio L. 2016. Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice. Mutagenesis. 2016 Jun 23. pii: gew028

Integration of metabolic activation w TGx signature to classify genotoxic vs nongenotoxic chemicals

October 6, 2015

J.K. Buick, I. Moffat, A. Williams, C.D. Swartz, L. Recio, D. R. Hyduke, H.H. Li, A.J. Fornace Jr, J. Aubrecht, C.L. Yauk. (2015) Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ Mol Mutagen 56:520–534. doi.org/10.1002/em.21940. PMID: 25733247

A predictive TGx signature to classify genotoxic vs non-genotoxic chemicals in human TK6 cells

October 6, 2015

Andrew Williams, Julie K. Buick, Ivy Moffat, Carol D. Swartz, Leslie Recio, Daniel R. Hyduke, Heng-Hong Li, Albert J. Fornace Jr., Jiri Aubrecht, Carole L. Yauk. (2015) A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells. Data in Brief. doi:10.1016/j.dib.2015.08.013

Impact of Genomics Platform & Statistics on Transcriptional BMD & Selection of Chemical PoD

October 6, 2015

Webster AF, Chepelev N, Gagné R, Kuo B, Recio L, Williams A, Yauk CL. (2015) Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD). PLoS One. Aug 27;10(8):e0136764. doi: 10.1371/journal.pone.0136764. PMID: 26313361

Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin

August 3, 2015

Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L , Koyanagi M, Hayashi SM. (2015) Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin. Food and Chemical Toxicology 83 (2015) 283-292.

JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay

June 1, 2015

Uno, Y., Kojima, H., Omori, T., Corvi, R., Honma, M., Schechtman, L.M., Tice, R.R., Beevers, C., De Boeck, M., Burlinson, B., Hobbs, C.A., Kitamoto, S., Kraynak, A.R., McNamee, J., Nakagawa, Y., Pant, K., Plappert-Helbig, U., Priestley, C., Takasawa, H., Wada, K., Wirnitzer, U., Asano, N., Escobar, P., Lovell, D., Morita, T., Nakajim, M., Ohno, Y., Hayashi, M. (2015) JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutation Research. 2015 Apr. 29

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis

April 7, 2015

Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.Hall JR, Messenger ZJ, Tam HW, Phillips SL, Recio L, Smart RC. Cell Death Dis. 2015 Mar 19

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice

April 7, 2015

Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan. Recio L, Phillips SL, Maynor T, Waters M , Jackson AF, Yauk CL. Toxicol Sci. 2013 Oct;135(2):369-79.

Comet assay evaluation of six chemicals of known genotoxic potential in rats

April 1, 2015

Hobbs CA L. Recio L, Streicker M, Boyle M , Tanaka J, Shiga A, Witt KL. Genet. Toxicol. Environ. Mutagen. (2015).

Cytotoxicity of naphthalene toward cells from target and non-target organs in vitro.

October 15, 2014

Kedderis GL, Shepard KG, Recio. L. 2014. Cytotoxicity of naphthalene toward cells from target and non-target organs in vitro. Chem Biol Interact. 209:85-95.

BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA changes.

October 15, 2014

Webster AF, Williams A, Recio L, Yauk CL. 2014. Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323C:26-31.

Biomarkers of Exposure and Effect in Human Lymphoblastoid TK6 Cells Following [13C2]-Acetaldehyde Ex

April 29, 2013

Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, and Swenberg JA. 2013. Biomarkers of Exposure and Effect in Human Lymphoblastoid TK6 Cells Following [13C2]-Acetaldehyde Exposure. Toxicol Sci. 133(1): 1-12. Editor’s Highlight

Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghatti

December 12, 2012

Maronpot, R., Davis, J., Moser, G., Giri, D., Hayashi, S. 2012. Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghatti. Food and Chemical Toxicology, 51: 215-224.

Comparison Comet Assay Dose-Response Ethyl Methanesulfonate Freshly Prepared Vs Cryoprepared Tissues

July 18, 2012

Recio, L., Kissling, G.E., Hobbs, C.A., and Witt, K.L. (2012) Comparison of Comet Assay Dose-Response for Ethyl Methanesulfonate Using Freshly Prepared Versus Cryopreserved Tissues. Environmental and Molecular Mutagenesis 53, 101-113. DOI: 10.1002/em.20694.

Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti

June 18, 2012

Hobbs, C.A., Swartz, C., Maronpot, R., Davis, J., Recio, L., and Hayashi, S. (2012) Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti. Food and Chemical Toxicology 50, 854-860. DOI: 10.1016/j.fct.2011.11.021.

Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats

June 18, 2012

Hobbs, C.A., Chhabra, R.S., Recio, L., Streicker, M. and Witt, K.L. (2012) Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats. Environmental and Molecular Mutagenesis 53, 227-238. DOI: 10.1002/em.21680

Assessment of Naphthalene-Induced Genotoxicity & Gluathione Detoxication in Human TK6 Lymphoblasts

March 26, 2012

Recio L, Shepard KG, Hernandez, LG, Kedderis GL. 2012. Dose-Response Assessment of Naphthalene-Induced Genotoxicity and Glutahione Detoxication in Human TK6 Lymphoblasts. Toxicol. Sci. 126(2):405-412.

Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti

December 21, 2011

Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L, and Hayashi S. 2011. Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti. Food and Chemical Toxicology DOI:10.1016/j.fct.2011.11.021.

Comet Assay Dose-Response for Ethyl Methanesulfonate Using Freshly Prepared Vs. Cryopreserved Tissue

November 26, 2011

Recio L, Kissling GE, Hobbs CA, and Witt KL, 2011. Comparison of Comet Assay Dose-Response for Ethyl Methansulfonate Using Freshly Prepared Versus Cryopreserved Tissues. Environmental and Molecular Mutagenesis (in press).

Genetic Toxicology in the 21st Century: Reflections and Future Directions

April 28, 2011

Mahadevan B, Snyder R, Waters M, Benz RD, Kemper RA, Tice RR and Richard AM. 2011. Genetic Toxicology in the 21st Century: Reflections and Future Directions. Environ. Mol. Mutagen. 52.

Characterizing and Predicting Carcinogenicity and Mode of Action

April 24, 2010

Waters M, Jackson MA, and Lea IA. 2010. Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods. Mutat Res 705: 184-200.

Dose-Response of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay

April 1, 2010

Recio L, Hobbs CA, Caspary W, Witt KL. 2010. Dose-Response Assessment of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay Protocol. Toxicol Sciences 35(2): 149-162.

No Biomarkers of Genetic Damage or Pathological Changes in Male Rats Administered Ritalin

January 1, 2010

Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. 2010. No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ Mol Mutagen 51(1): 80-88.