Publications 2017-12-19T22:50:06+00:00

Publications

Services

Names of ILS employees are shown in boldface font:

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays

June 11, 2018

Debabrata Mahapatra, Jill A. Franzosa, Kyle Roell, Melaine Agnes Kuenemann, Keith A. Houck, David M. Reif, Denis Fourches & Seth W. Kullman

Open-source Workflows for In Vitro to In Vivo Extrapolation

March 16, 2017

X Chang, SM Bell, JR Pirone, D Allen, W Casey, N Kleinstreuer. 2017. Open-source Workflows for In Vitro to In Vivo Extrapolation. Presented at SOT Annual Meeting on March 16, 2017 (Abstract # 3185 )

Development of a Curated Database of In Vivo Developmental Toxicity Data

March 16, 2017

P Ceger, N Choksi, J Hamm, J Truax, A Daniel, D Allen, V Sutherland, B McIntyre, P Foster, E Maull, W Casey. 2017. Development of a Curated Database of In Vivo Developmental Toxicity Data. Presented at SOT Annual Meeting on March 16, 2017 (Abstract #3159)

An Integrated Chemical Environment to Support 21st Century Toxicology

March 15, 2017

SM Bell, J Phillips, A Sedykh, C Sprankle, S Morefield, D Allen, W Casey, N Kleinstreuer. 2017. An Integrated Chemical Environment to Support 21st Century Toxicology. Presented at SOT Annual Meeting on March 15, 2017 (Abstract # 2935)

Prediction of Skin Sensitization Potency Using Machine Learning Approaches

March 15, 2017

J Strickland, Q Zang, M Paris, DM Lehmann, S Bell, D Allen, J Matheson, A Jacobs, W Casey, N Kleinstreuer. 2017. Prediction of Skin Sensitization Potency Using Machine Learning Approaches. Presented at SOT Annual Meeting on March 15, 2017 (Abstract #2915)

Identification, Curation, and Prioritization of Food-Use Chemicals in ToxCast

March 15, 2017

M Krishan, TD Trautman, DF Kapraun, LA Fix, and AL Karmaus. 2017. Identification, Curation, and Prioritization of Food-Use Chemicals in ToxCast. Presented at SOT Annual Meeting on March 15, 2017 (Abstract #2559)

Integrated decision strategies for skin sensitization hazard

March 14, 2016

Strickland J, Zang Q, Kleinstreuer N, Paris M, Lehmann DM, Choksi N, Matheson J, Jacobs A, Lowit A, Allen D, Casey W. 2016. Integrated decision strategies for skin sensitization hazard. Journal of Applied Toxicology. 2016 Feb 6. doi: 10.1002/jat.3281.

Accelerating adverse outcome pathway development using publicly available data sources

March 14, 2016

Oki NO, Nelms MD, Bell SM, Mortensen HM, Edwards SW. 2016. Accelerating adverse outcome pathway development using publicly available data sources. Curr Environ Health Rep. 2016 Mar;3(1):53-63.

Adverse Outcome Pathways: From Research to Regulation. Scientific workshop report

March 14, 2016

Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. 2016. Adverse Outcome Pathways: From Research to Regulation. Scientific workshop report. Regulatory Toxicology & Pharmacology. 2016 Jan 14;76:39-50 doi: 10.1016/j.yrtph.2016.01.007

Performance of the BG1Luc ER TA method in a qHTS format

February 8, 2016

Ceger P, Allen D, Huang R, Xia M, Casey W. Performance of the BG1Luc ER TA method in a qHTS format. ALTEX. 2015 Jun 28. doi: 10.14573/altex.1505121

Bayesian Integrated Testing Strategy (ITS) for Skin Sensitization Potency Assessment

December 8, 2015

Jaworska JS,· Natsch A, Ryan C, · Strickland J, ·Ashikaga T, · Miyazawa M. 2015. Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy. Arch Toxicol. 2015 Dec; doi: 10.1007/s00204-015-1634-2

TGx & traditional approaches to inform MoA and PoD in health risk assessment of benzo[a]pyrene

October 6, 2015

Moffat I, Chepelev NL, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Williams A, Halappanavar S, Malik AI, Luijten M, Aubrecht J, Hyduke DR, Fornace AJ Jr, Swartz CD, Recio L, Yauk CL. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol. 45(1):1-43. doi: 10.3109/10408444.2014.973934. Review. PMID: 25605026

Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability

January 20, 2015

Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer NC, Andrade CH, Tropsha A. (2015) Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization. Toxicology and Applied Pharmacology,

Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization

January 20, 2015

Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer NC, Andrade CH, Tropsha A. (2015) Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds. Toxicology and Applied Pharmacology,

t4 workshop report: Integrated Testing Strategies (ITS) for Safety Assessment ALTEX

December 5, 2014

Rovida C, Alépée N, Api AM, Basketter DA, Bois FY, Caloni F, Corsini E, Daneshian M, Eskes C, Ezendam J, Fuchs H, Hayden P, Hegele-Hartung C, Hoffmann S, Hubesch B, Jacobs MN, Jaworska J, Kleensang A, Kleinstreuer N, Lalko J, Landsiedel R, Lebreux F, Luechtefeld T, Locatelli M, Mehling A, Natsch A, Pitchford JW, Prater D, Prieto P, Schepky A, Schuurmann G, Smirnova L, Toole C, van Vliet E, Weisensee D, Hartung T. 2014. t4 workshop report: Integrated Testing Strategies (ITS) for Safety Assessment ALTEX (in press).

Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity

December 5, 2014

Chang X, Kleinstreuer N, Ceger P, Hsieh J-H, Allen D, Casey W. Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity. Applied In Vitro Toxicology (in press).

Immediate and long-term consequences of vascular toxicity during zebrafish development

December 5, 2014

Tal TL, McCollum CW, Harris PS, Olin J, Kleinstreuer N, Wood CE, Hans C, Shah S, Merchant FA, Bondesson M, Knudsen TB, Padilla S, Hemmer MJ. 2014. Immediate and long-term consequences of vascular toxicity during zebrafish development. Reprod Toxicol 48:51–61.

Open source software implementation of an integrated testing strategy for skin sensitization potency

December 5, 2014

Pirone JR, Smith M, Kleinstreuer NC, Burns TA, Strickland J, Dancik Y, Morris R, Rinckel LA, Casey W, Jaworska JA. 2014. Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network. ALTEX 31: 336–340.

Comments how to make the new vision of toxicity testing in the 21st century a reality

December 5, 2014

McKim A, Goldberg A, Kleinstreuer N, Busquet F, Andersen M. 2014. Roundtable discussion: Comments on how to make the new vision of toxicity testing in the 21st century a reality. Applied In Vitro Toxicology 1(1): 5–10.

t4 workshop report: Lessons Learned, Challenges, and Opportunities: The U.S. EDSP

December 5, 2014

Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG, Willett CE, Andersen ME, Borgert CJ, Coady KK, Dourson ML, Fowle JR, Gray LE, Lamb JC, Ortego LS, Schug TT, Toole CM, Zorrilla LM, Kroner OL, Patterson J, Rinckel LA, Jones BR. 2014. t4 workshop report: Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program. ALTEX 31:63-78.

Report on the International Workshop on Alternatives to the Murine Histamine Sensitization Test

December 5, 2014

Isbrucker R, Arciniega J, McFarland R, Chapsal J-M, Xing D, Bache C, Nelson S, Costanzo A, Hoonakker M, Castiaux A, Halder M, Casey W, Johnson N, Jones B, Doelling V, Sprankle C, Rinckel L, Stokes W. 2014. Report on the International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward. Biologicals 42(2):114-122.

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor

December 5, 2014

Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh J-H, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M. 2014. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Nature Scientific Reports

Quantitative profiling of environmental chemicals and drugs that modulate farnesoid X receptor

November 5, 2014

Hsu CW, Zhao J, Huang R, Hsieh J-H, Hamm J, Chang X, Houck K, M Xia. 2014. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Nature Scientific Reports

Performance standards and alternative assays: practical insights from skin sensitization.

August 28, 2013

Kolle SN, Basketter DA, Casati S, Stokes WS, Strickland J, van Ravenzwaay B, Vohr HW, and Landsiedel R. 2013. Performance standards and alternative assays: Practical insights from skin sensitization. Regul Toxicol Pharmacol 65: 278-85.

A computational model predicting disruption of blood vessel development.

August 28, 2013

Kleinstreuer N, Dix D, Rountree M, Baker N, Sipes N, Reif D, Spencer R, Knudsen T. (2013) A Computational Model Predicting Disruption of Blood Vessel Development. PLoS Comput Biol 9(4): e1002996.

A C. elegans Screening Platform for the Rapid Assessment of Chemical Disruption of Germline Function

April 28, 2013

Allard P, Kleinstreuer N, Knudsen T, Colaiacovo M. (2013) A novel chemical screening strategy for assessing environmental germline disruption in C. Elegans. Env Health Persp doi:10.1289/ehp.1206301.

Report on the International Workshop on Alternative Methods for Human & Veterinary Rabies Vaccines

August 14, 2012

Stokes W, McFarland R, Kulpa-Eddy J, Gatewood D, Levis R, Halder M, Pulle G, Kojima H, Casey W, Gaydamaka A, Miller T, Brown K, Lewis C, Chapsal, Bruckner L, Gairola S, Kamphuis E, Rupprecht CE, Wunderli P, McElhinney L, De Mattia F, Gamoh K, Hill R, Reed D, Doelling V, Johnson N, Allen D, Rinckel L, and Jones B. 2012. Report on the International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward. Biologicals.

Improving Animal Welfare and Reducing Animal Use for Veterinary Vaccine Potency Testing

January 23, 2012

Stokes WS, Brown K, Kulpa-Eddy J, Srinivas G, Halder M, Draayer H, Galvin J, Claasen I, Gifford G, Woodland R, Doelling V, Jones B. 2011. Improving Animal Welfare and Reducing Animal Use for Veterinary Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):84-105.

Alt. Methods to Reduce, Refine & Replace Animal Use for Veterinary Vaccine Post-Licensing Testing

January 13, 2012

Kulpa-Eddy J, Srinivas G, Halder M, Brown K, Draayer H, Glavin J, Claassen I, Gifford G, Woodland R, Doelling V, Jones, B, Stokes WS. 2011. Alternative Methods and Strategices to Reduce, Refine and Replace Animal Use for Veterinary Vaccine Post-Licensing Safety Testing: State of the The Science and Future Directions.Procedia in Vaccinology(5):106-119.

Alternative Methods to Reduce, Refine & Replace Animal Use for Human Vaccine Post-Licensing Testing

January 13, 2012

Isbrucker R, Levis R, Casey W, McFarland R, Schmitt M, Arciniega J, Descamps J, Finn T, Hendriksen C, Horiuchi Y, Keller J, Kojima H, Sesardic D, Stickings P, Johnson NW, Allen D. 2011. Alternative Methods and Strategies to Reduce, Refine and Replace Animal Use for Human Vaccine Post-Licensing Safety Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):47-59.

Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing

January 13, 2012

Kulp-Eddy J, Srinivas G, Halder M, Hill R, Brown K, Roth J, Draayer H, Galvin G, Woodland R, Doelling V, Jones B, Stokes WS. 2011. Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):60-83.

Improving Animal Welfare and Reducing Animal Use for Human Vaccine Potency Testing

January 13, 2012

Casey W, Schmitt M, McFarland R, Isbrucker R, Levis R, Arciniega J, Descamps J, Finn T, Hendriksen C, Horluchi Y, Keller, J, Kojima H, Sesardic D, Stickings P, Johnson NW, Lipscomb E, Allen D. 2011. Improving Animal Welfare Reducing Animal Use for Human Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):33-46.

Non-Animal Replacement Methods for Human Potency Testing: State of the Science and Future Directions

January 13, 2012

McFarland R, Verthelyi D, Casey W, Arciniega J, Isbrucker R, Schmitt M, Finn T, Descamps J, Horiuchi Y, Sesardic D, Stickings P, Johnson NW, Lipscomb E, Allen D. 2011. Non-Animal Replacement Methods for Human Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5): 16-32.

Using Fewer Animals to Identify Chemical Eye Hazards: Criteria to Maintain Hazard Classification

October 20, 2011

Haseman JK,Allen DG,Lipscomb EA,Truax JF,Stokes WS. 2011. Using Fewer Animals to Identify Chemical Eye Hazards: Revised Criteria Necessary to Maintain Equivalent Hazard Classification. Regulatory Toxicology and Pharmacology 61:98-104.

Safety Assessment of Allergic Contact Dermatitis Hazards: An Analysis Supporting Reduced Animal Use

September 22, 2011

Haseman JK,Strickland J,Allen D,Salicru E,Paris M,Tice RR,Stokes WS. 2011. Safety Assessment of Allergic Contact Dermatitis Hazards: An Analysis Supporting Reduced Animal Use for the Murine Local Lymph Node Assay. Regulatory Toxicology and Pharmacology 59: 191-96.