Names of ILS employees are shown in boldface font:
Transcriptomic pathway and benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3′,5,5′-Tetrabromobisphenol A in H9 human embryonic stem cells
January 25, 2021
Vian Peshdary, Cheryl A. Hobbs, Timothy Maynorc, Kim Shepard, Remi Gagné, Andrew Williams, Byron Kuo, Nikolai Chepelev, Leslie Recio, Carole Yauk, Ella Atlas
A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs
January 24, 2021
Mind the gaps: Prioritizing activities to meet regulatory needs for acute systemic lethality
January 21, 2021
Sullivan, K., Allen, D. G., Clippinger, A. J., Wilson, D. M., Edwards, S. W., Glover, K., Mansouri, K., Settivari, R., Wijeyesakere, S. J. and Casey, W.
Training with Multiple Structurally Related Odorants Fails to Improve Generalization of Ammonium Nitrate Detection in Domesticated Dogs (Canis Familiaris)
January 16, 2021
David C Dorman, Melanie L Foster, Lucia Lazarowski
Using the monocyte activation test as a stand-alone release test for medical devices
January 12, 2021
Brown, J., Clippinger, A. J., Fritz Briglia, C. ., Casey, W., Coleman, K., Fritsch, A., Hartung, T., Maouyo, D., Muller, T., Reich, J., Robert, L., Roeder, R., Sanchez, G., Sawyer, A. Y., Solati, S., Tirumalai, R., Zwisler, W. and Allen, D.
Using Artificial Intelligence to Detect, Classify, and Objectively Score Severity of Rodent Cardiomyopathy
December 9, 2020
Debra A. Tokarz, Thomas J. Steinbach, Avinash Lokhande, Gargi Srivastava, Rajesh Ugalmugle, Caroll A. Co, Keith R. Shockley, Emily Singletary, Mark F. Cesta, Heath C. Thomas, Vivian S. Chen, Kristen Hobbie, Torrie A. Crabbs
A weight of evidence assessment of the genotoxicity of 2,6-xylidine based on existing and new data, with relevance to safety of lidocaine exposure.
December 7, 2020
David J. Kirkland, Meredith, L. Sheil, Michael A. Streicker, George E. Johnson
Assessing Rodent Gnawing of Elastomers Containing Soybean Oil Derivatives
December 7, 2020
Richard P. Heggs, Brian C. Pierce, Lisa M. Balbes, Keenan C. McRoberts, Michael A. Streicker, and Keith B. Cockerline
An evaluation of the performance of selected (Q)SARs/expert systems for predicting acute oral toxicity.
November 1, 2020
Nelms MD, Karmaus AL, Patlewicz G
Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms
October 16, 2020
Wetendorf M, R Li, SP Wu, J Liu, CJ Creighton, T Wang, KS Janardhan, CJ Willson, RB Lanz, BD Murphy, JP Lydon and FJ DeMayo
Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish
October 1, 2020
Megan M. Knuth, Debabrata Mahapatra, Dereje Jima, Debin Wan, Bruce D. Hammock, Mac Law & Seth W. Kullman
Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats
June 23, 2020
Kristen R. Hobbie, Darlene Dixon
An integrated chemical environment with tools for chemical safety testing
June 14, 2020
Bell S, Abedini J, Ceger P, Chang X, Cook B, Karmaus AL, Lea, I, Mansouri K, Phillips J, McAfee E, Rai R, Rooney J, Sprankle C, Tandon A, Allen D, Casey W, and Kleinstreuer N
Challenges and recommendations on the conduct of systematic reviews of observational epidemiologic studies in environmental and occupational health
June 11, 2020
Whitney D. Arroyave, Suril S. Mehta, Neela Guha, Pam Schwingl, Kyla W. Taylor, Barbara Glenn, Elizabeth G. Radke, Nadia Vilahur, Tania Carreón, Rebecca M. Nachman & Ruth M. Lunn
https://www.nature.com/articles/s41370-020-0228-0
Development, Validation and Integration of in Silico Models to Identify Androgen Active Chemicals
June 9, 2020
Retinal cone photoreceptor distribution in the American black bear (Ursus americanus)
June 8, 2020
Jennifer L. Heyward Benjamin D. Reynolds Melanie L. Foster Kate E. Archibald Michael K. Stoskopf Freya M. Mowat
In utero exposure to arsenite contributes to metabolic and reproductive dysfunction in male offspring of CD-1 mice
May 29, 2020
Karina Rodriguez, Namya Mellouk, Erica Ungewitter, Barbara Nicol, Chang Liu, Paula R. Brown, Cynthia J. Willson, Humphrey H.-C.Yao
Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case-control study
April 8, 2020
Freya M Mowat, Janelle Avelino, Ashley Bowyer, Vanessa Parslow, Hans D Westermeyer, Melanie L Foster, Jonathan E Fogle, Petra Bizikova
Multigenerational Reproductive Assessment of 4-Methylimidazole administered in the diet to Hsd:Sprague Dawley SD rats
March 31, 2020
Mamta Behl, Cynthia J. Willson, Helen Cunny, Paul M.D.Foster, Barry McIntyre, Cynthia Shackelford, Keith R. Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R. Blystone
Methods for Cryosectioning and Mass Spectrometry Imaging of Whole-Body Zebrafish
March 19, 2020
Whitney L. Stutts, Megan M. Knuth, Måns Ekelöf, Debabrata Mahapatra, Seth W. Kullman, David C. Muddiman
New Perspectives for Cancer Hazard Evaluation by the Report on Carcinogens: A Case Study Using Read-Across Methods in the Evaluation of Haloacetic Acids Found as Water Disinfection By-Products
December 19, 2019
Stanley T. Atwood, Ruth M. Lunn, Sanford C. Garner, and Gloria D. Jahnke
A Prospective Analysis of Red and Processed Meat Consumption and Risk of Colorectal Cancer in Women
December 16, 2019
Suril S. Mehta, Whitney D. Arroyave, Ruth M. Lunn, Yong-Moon Mark Park, Windy A. Boyd and Dale P. Sandler
Previously Diagnosed Reticulum Cell Hyperplasia in Decalcified Rat Bone Marrow Stain Positive for Ionized Calcium Binding Adapter Molecule 1 (Iba1): A Monocytic/Macrophage Cell Marker
December 12, 2019
Michelle C. Cora, Kyathanahalli S. Janardhan, Heather Jensen, Natasha Clayton, Gregory S. Travlos
Proceedings of the 2019 National Toxicology Program Satellite Symposium
November 1, 2019
Susan A. Elmore, Mark F. Cesta, Torrie A. Crabbs, Kyathanahalli S. Janardhan, Gregory A. Krane, Debabrata Mahapatra, Erin M. Quist, Matthias Rinke, George W. Schaaf, Gregory S. Travlos, Haoan Wang, Cynthia J. Willson, and Jeffrey C. Wolf
Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace
October 14, 2019
Wan-Chi Lin, Kymberly M. Gowdy, Jennifer H. Madenspacher, Rachel L. Zemans, Kazuko Yamamoto, Miranda R. Lyons-Cohen, Hideki Nakano, Kyathanahalli Janardhan, Carmen J. Williams, Donald N. Cook, Joseph P. Mizgerd, and Michael B. Fessler
Integrated in silico and in vitro genotoxicity assessment of thirteen data-poor substances.
October 14, 2019
Tran YK, Buick JK, Keir JLA, Williams A, Swartz CD , Recio L, White PA, Lambert IB, Yauk CL
National Toxicology Program Position Statement on Informed (“Nonblinded”) Analysis in Toxicologic Pathology Evaluation
September 20, 2019
Robert C. Sills, Mark F. Cesta, Cynthia J. Willson, Amy E. Brix, Brian R. Berridge
Looking Forward: Cutting-Edge Technologies and Skills for Pathologists in the Future
September 17, 2019
Kyathanahalli S. Janardhan, Rebecca Kohnken, Oliver C. Turner, Channabasavaiah B. Gurumurthy, Ramesh C. Kovi
Comparative Incidences and Biological Outcomes for Thymoma in Various Rat Strains in National Toxicology Program Studies.
August 13, 2019
Moore RR, Nagai H, Miller RA, Hardisty JF, Allison N, Shockley KR, Malarkey DE
Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis
July 31, 2019
Pengcheng Chen, Shang Wang, Kyathanahalli S. Janardhan, Rachel L. Zemans, Wenhai Deng, Peer Karmaus, Shudan Shen, Mary Sunday, Loretta G. Que, Michael B. Fessler and Xiao-Ping Zhong
ERBB2 Regulates MED24 during Cancer Progression in Mice with Pten and Smad4 Deletion in the Pulmonary Epithelium
July 31, 2019
Jian Liu, Tianyuan Wang, Cynthia J. Willson, Kyathanahalli S. Janardhan, San-Pin Wu, Jian-Liang Li and Francesco J. DeMayo
Do GISTs Occur in Rats and Mice? Immunohistochemical Characterization of Gastrointestinal Tumors Diagnosed as Smooth Muscle Tumors in The National Toxicology Program
July 31, 2019
Kyathanahalli S. Janardhan, Priyanka Venkannagari, Heather Jensen, Mark J. Hoenerhoff, Ronald A. Herbert, David E. Malarkey, Robert C. Sills, Arun R. Pandiri
JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression
July 31, 2019
Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis & Francesco J. DeMayo
Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)
July 31, 2019
Folami Y Ideraabdullah, Anthony M Belenchia, Cheryl S Rosenfeld, Seth W Kullman, Megan Knuth, Debabrata Mahapatra, Michael Bereman, Edward D Levin, and Catherine A Peterson
Proceedings of the 2018 National Toxicology Program Satellite Symposium
October 8, 2018
Susan A. Elmore, Vinicius Carreira, Caralyn S. Labriola, Debabrata Mahapatra, Sean R. McKeag, Matthias Rinke, Cynthia Shackelford, Bhanu Singh, Ashley Talley, Shannon M. Wallace, Lyn M. Wancket, Cynthia J. Willson
Differentiating between Testicular Toxicity and Sexual Immaturity in Ortho-phthalaldehyde Inhalation Toxicity Studies in Rats and Mice
October 8, 2018
Natasha R. Catlin, Cynthia J. Willson, Dianne M. Creasy, Deepa B. Rao, Grace E. Kissling, Barry S. McIntyre, Michael Wyde
Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays
June 11, 2018
Debabrata Mahapatra, Jill A. Franzosa, Kyle Roell, Melaine Agnes Kuenemann, Keith A. Houck, David M. Reif, Denis Fourches & Seth W. Kullman
Genotoxicity evaluation of the naturally-derived food colorant, gardenia blue, and its precursor, genipin
June 4, 2018
Cheryl Hobbs, Mihoko Koyanagi, Carol Swartz, Jeffrey Davis, Robert Maronpot, Leslie Recio, Shim-mo Hayashi
Carcinogenic activity of pentabrominated diphenyl ether mixture (DE-71) in rats and mice
May 14, 2018
J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, A. Brix
Role of pathology peer review in interpretation of the comet assay
May 11, 2018
R. R. Maronpot, Cheryl A. Hobbs, Shim-mo Hayashi
Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells
April 25, 2018
Transcriptional profiling of male CD-1 mouse lungs and harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors
February 26, 2018
Nikolai L. Chepeleva, Rémi Gagné, Timothy Maynor, Byron Kuo, Cheryl A. Hobbs, Leslie Recio, Carole L. Yauk
Magnesium stearate, a widely-used food additive, exhibits a lack of in vitro and in vivo genotoxic potential
February 26, 2018
Cheryl A. Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-mo Hayashi
Comprehensive evaluation of the flavonol anti-oxidants, alpha-glycosyl isoquercitrin and isoquercitrin, for genotoxic potential
February 23, 2018
Comparative inhalation toxicity of ethyltoluene isomers in rats and mice
January 29, 2018
Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey &
Daniel L. Morgan
In Vitro to In Vivo extrapolation for high throughput prioritization and decision making
January 3, 2018
Bell SM, Chang X, Wambaugh JF, Allen DG, Bartels M, Brouwer KLR, Casey WM, Choksi N, Ferguson SS, Fraczkiewicz G, Jarabek AM, Ke A, Lumen A, Lynn SG, Paini A, Price PS, Ring C, Simon TW, Sipes N, Sprankle CS, Strickland J, Troutman J, Wetmore BA, Kleinstreuer NC. 2017. In vitro to in vivo extrapolation for high throughput prioritization and decision making. Toxicology In Vitro. 2017 Dec 5. doi:10.1016/j.tiv.2017.11.016
Open-source Workflows for In Vitro to In Vivo Extrapolation
March 16, 2017
X Chang, SM Bell, JR Pirone, D Allen, W Casey, N Kleinstreuer. 2017. Open-source Workflows for In Vitro to In Vivo Extrapolation. Presented at SOT Annual Meeting on March 16, 2017 (Abstract # 3185 )
Development of a Curated Database of In Vivo Developmental Toxicity Data
March 16, 2017
P Ceger, N Choksi, J Hamm, J Truax, A Daniel, D Allen, V Sutherland, B McIntyre, P Foster, E Maull, W Casey. 2017. Development of a Curated Database of In Vivo Developmental Toxicity Data. Presented at SOT Annual Meeting on March 16, 2017 (Abstract #3159)
Impact of Acrylamide on Calcium Signaling and Cytoskeletal Filaments in Testes From F344 Rat.
March 16, 2017
Leslie Recio, Marvin Friedman, Dennis Marroni, Timothy Maynor, Nikolai Chepelev
An Integrated Chemical Environment to Support 21st Century Toxicology
March 15, 2017
SM Bell, J Phillips, A Sedykh, C Sprankle, S Morefield, D Allen, W Casey, N Kleinstreuer. 2017. An Integrated Chemical Environment to Support 21st Century Toxicology. Presented at SOT Annual Meeting on March 15, 2017 (Abstract # 2935)
Prediction of Skin Sensitization Potency Using Machine Learning Approaches
March 15, 2017
J Strickland, Q Zang, M Paris, DM Lehmann, S Bell, D Allen, J Matheson, A Jacobs, W Casey, N Kleinstreuer. 2017. Prediction of Skin Sensitization Potency Using Machine Learning Approaches. Presented at SOT Annual Meeting on March 15, 2017 (Abstract #2915)
Identification, Curation, and Prioritization of Food-Use Chemicals in ToxCast
March 15, 2017
M Krishan, TD Trautman, DF Kapraun, LA Fix, and AL Karmaus. 2017. Identification, Curation, and Prioritization of Food-Use Chemicals in ToxCast. Presented at SOT Annual Meeting on March 15, 2017 (Abstract #2559)
In Vitro Micronucleus and CometChip with Metabolically Competent HepaRG Cells
March 14, 2017
Swartz, CD, Winters, J, Owens, K, Yauk, CL, Buick, J, Ngo, L, Engelward, B, and Recio, L. 2017. In Vitro Micronucleus® and CometChip with Metabolically Competent HepaRG™ Cells. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 2267)
Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues
March 14, 2017
Chepelev NL, Gagné R, Maynor T, Hobbs CA, Kuo B, Yauk CL, Recio L. 2017. Acrylamide Perturbs Calcium and Actin Cytoskeleton Signaling in Rat and Mouse Cancer Target Tissues. Presented at SOT Annual Meeting on March 14, 2017 (Abstract # 1830)
Customizing the Connectivity Map Approach for Functional Evaluation in Toxicogenomics Studies
March 13, 2017
Karmaus AL, Kothiya P, Watford S, Thomas RS, Martin MT. 2017. Customizing the Connectivity Map Approach for Functional Evaluation in Toxicogenomics Studies. Presented at SOT Annual Meeting on March 13, 2017 (Abstract #1374)
Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks
March 13, 2017
Hobbs CA, Sinha N, Chepelev N, Gagné R, Christy N, Yauk CL, Recio L. 2017. Toxicogenomics Reveals Dynamic Baseline Changes and Overlapping Effects of Epigenotoxicant Exposure on Stem Cell Differentiation and Tissue Development Networks. Presented at SOT Annual Meeting on March 13, 2017 (Abstract #1344)
Ninety-day toxicity and single-dose toxicokinetics study of AGIQ in Sprague-Dawley rats
September 27, 2016
Nyska A, Hayashi S, Koyanagi M, Davis J, Jokinen M, Ramot Y, Maronpot R. 2016. Ninety-day toxicity and single-dose toxicokinetics study of alphaglycosyl isoquercitrin in Sprague-Dawley rats. Food and Chemical Toxicology. 2016 Sep 27. pii: S0278-6915(16)30346-5.
Genotoxicity assessment of the flavouring agent, perillaldehyde
September 1, 2016
Hobbs C, Taylor S, Beevers C, Lloyd M, Bowen R, Lillford L, Maronpot R, Hayashi S. 2016. Genotoxicity assessment of the flavouring agent, perillaldehyde. Food and Chemical Toxicology. 2016 Sep 1;97:232-242. doi: 10.1016/j.fct.2016.08.029.
Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents
July 1, 2016
Morgan D, Jokinen M, Johnson C, Price H, Gwinn W, Bousquet R, Flake G. 2016. Chemical Reactivity and Respiratory Toxicity of the alpha-Diketone Flavoring Agents: 2,3-Butanedione, 2,3-Pentanedione, and 2,3-Hexanedione. Toxicologic Pathology. 2016 Jul;44(5):763-83. doi: 10.1177/0192623316638962.
Differential genotoxicity of acrylamide in the MN and Pig-a assays in F344 rats and B6C3F1 mice
June 23, 2016
Hobbs CA, Davis J, Shepard K, Chepelev N, Friedman M, Marroni D, Recio L. 2016. Differential genotoxicity of acrylamide in the micronucleus and Pig-a gene mutation assays in F344 rats and B6C3F1 mice. Mutagenesis. 2016 Jun 23. pii: gew028
Advancing toxicology research using in vivo high throughput toxicology with small fish models
June 21, 2016
Planchart A, Mattingly CJ, Allen D, Ceger P., Casey W, Hinton D, Kanungo J, Kullman SW, Tal T, Bondesson M, Burgess SM, Sullivan C, Kim C, Behl M, Padilla S, Reif DM, Tanquay RL, Hamm J. 2016. Advancing toxicology research using in vivo high throughput toxicology with small fish models. Altex. 2016 Jun 21. doi: 10.14573/altex.1601281.
Integrated decision strategies for skin sensitization hazard
March 14, 2016
Strickland J, Zang Q, Kleinstreuer N, Paris M, Lehmann DM, Choksi N, Matheson J, Jacobs A, Lowit A, Allen D, Casey W. 2016. Integrated decision strategies for skin sensitization hazard. Journal of Applied Toxicology. 2016 Feb 6. doi: 10.1002/jat.3281.
Accelerating adverse outcome pathway development using publicly available data sources
March 14, 2016
Oki NO, Nelms MD, Bell SM, Mortensen HM, Edwards SW. 2016. Accelerating adverse outcome pathway development using publicly available data sources. Curr Environ Health Rep. 2016 Mar;3(1):53-63.
Adverse Outcome Pathways: From Research to Regulation. Scientific workshop report
March 14, 2016
Kleinstreuer NC, Sullivan K, Allen D, Edwards S, Mendrick DL, Embry M, Matheson J, Rowlands JC, Munn S, Maull E, Casey W. 2016. Adverse Outcome Pathways: From Research to Regulation. Scientific workshop report. Regulatory Toxicology & Pharmacology. 2016 Jan 14;76:39-50 doi: 10.1016/j.yrtph.2016.01.007
Enhanced stability of TTP mRNA protects mice against immune-mediated inflammatory pathologies
February 8, 2016
Patial S, Curtis AD, Lai WS, Stumpo DJ, Hill GD, Flake GP, Mannie MD, Blackshear PJ. Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. Proc Natl Acad Sci U S A. 2016 Feb 1. pii: 201519906.
Performance of the BG1Luc ER TA method in a qHTS format
February 8, 2016
Ceger P, Allen D, Huang R, Xia M, Casey W. Performance of the BG1Luc ER TA method in a qHTS format. ALTEX. 2015 Jun 28. doi: 10.14573/altex.1505121
Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis
December 14, 2015
Ippolito DL, AbdulHameed MD, Tawa GJ, Baer CE, Permenter MG, McDyre BC, Dennis WE, Boyle MH, Hobbs CA, Streicker MA , Snowden BS, Lewis JA, Wallqvist A, Stallings JD.Gene expression patterns associated with histopathology in toxic liver fibrosis. Toxicol Sci. 2015 Sep 22. pii: kfv214.
Bayesian Integrated Testing Strategy (ITS) for Skin Sensitization Potency Assessment
December 8, 2015
Jaworska JS,· Natsch A, Ryan C, · Strickland J, ·Ashikaga T, · Miyazawa M. 2015. Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy. Arch Toxicol. 2015 Dec; doi: 10.1007/s00204-015-1634-2
Utilizing Whole Slide Images for Pathology Peer Review and Working Groups
November 13, 2015
Malarkey DE, Willson GA, Willson CJ, Adams ET, Olson GR, Witt WM, Elmore SA, Hardisty JF, Boyle MC, Crabbs TA, Miller RA. (2015) Utilizing Whole Slide Images for Pathology Peer Review and Working Groups. Toxicol Pathol. 2015 Oct 27. pii: 0192623315605933
IHC Expression of Cyclin D1, Cytokeratin 20, & Uroplakin III Induced by o-Nitroanisole
October 6, 2015
Cynthia J. Willson, Gordon P. Flake, Robert C. Sills, Grace E. Kissling, and Mark F. Cesta. (2015) Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats. Veterinary Pathology, first published on August 28, 2015 as doi:10.1177/0300985815603432
Integration of metabolic activation w TGx signature to classify genotoxic vs nongenotoxic chemicals
October 6, 2015
J.K. Buick, I. Moffat, A. Williams, C.D. Swartz, L. Recio, D. R. Hyduke, H.H. Li, A.J. Fornace Jr, J. Aubrecht, C.L. Yauk. (2015) Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells. Environ Mol Mutagen 56:520–534. doi.org/10.1002/em.21940. PMID: 25733247
A predictive TGx signature to classify genotoxic vs non-genotoxic chemicals in human TK6 cells
October 6, 2015
Andrew Williams, Julie K. Buick, Ivy Moffat, Carol D. Swartz, Leslie Recio, Daniel R. Hyduke, Heng-Hong Li, Albert J. Fornace Jr., Jiri Aubrecht, Carole L. Yauk. (2015) A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells. Data in Brief. doi:10.1016/j.dib.2015.08.013
Impact of Genomics Platform & Statistics on Transcriptional BMD & Selection of Chemical PoD
October 6, 2015
Webster AF, Chepelev N, Gagné R, Kuo B, Recio L, Williams A, Yauk CL. (2015) Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD). PLoS One. Aug 27;10(8):e0136764. doi: 10.1371/journal.pone.0136764. PMID: 26313361
TGx & traditional approaches to inform MoA and PoD in health risk assessment of benzo[a]pyrene
October 6, 2015
Moffat I, Chepelev NL, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Williams A, Halappanavar S, Malik AI, Luijten M, Aubrecht J, Hyduke DR, Fornace AJ Jr, Swartz CD, Recio L, Yauk CL. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Crit Rev Toxicol. 45(1):1-43. doi: 10.3109/10408444.2014.973934. Review. PMID: 25605026
BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA in mouse
October 6, 2015
Webster AF, Williams A, Recio L, Yauk CL. (2014) Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323:26-31. doi: 10.1016/j.tox.2014.06.002. PMID: 24910943
Mining the archives: a cross-platform analysis of gene expression profiles in archival FFPE tissue
October 6, 2015
Webster AF, Zumbo P, Fostel J, Gandara J, Hester SD, Recio L, Williams A, Wood CE, Yauk CL, Mason CE. (2015) Mining the archives: a cross-platform analysis of gene expression profiles in archival formalin-fixed paraffin-embedded (FFPE) tissue. Toxicol Sci. [Epub ahead of print] PMID: 26361796
Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in rats
September 21, 2015
Robert R. Maronpot, Mihoko Koyanagi, Jeffrey Davis, Leslie Recio, Dean Marbury, Molly Boyle & Shim-Mo Hayashi. (2015) Safety assessment and single-dose toxicokinetics of the flavouring agent, myricitrin, in Sprague Dawley rats. Food Additives & Contaminants: Part A (2015).
Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin
August 3, 2015
Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L , Koyanagi M, Hayashi SM. (2015) Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin. Food and Chemical Toxicology 83 (2015) 283-292.
Histopathological and Immunohistochemical Characterization of Cell Leisons in Stomach of Rats
July 24, 2015
Janardhan KS , Rebolloso Y, Hurlburt G, Olson D, Lyght O, Clayton NP, Gruebbel M, Picut C, Shackelford C, Herbert RA. (2015) Histopathological and Immunohistochemical Characterization of Methly Eugenol-induced Nonneoplastic and Neoplastic Neuroendocrine Cell Lesions in Glandular Stomach of Rats. Toxicologic Pathology. 2015 Jul.
Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats
July 15, 2015
Willson, C.J., Herbert, R.A., Cline, J.M. (2015) Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats. Toxicologic Pathology. 2015 Jul. 7
JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay
June 1, 2015
Uno, Y., Kojima, H., Omori, T., Corvi, R., Honma, M., Schechtman, L.M., Tice, R.R., Beevers, C., De Boeck, M., Burlinson, B., Hobbs, C.A., Kitamoto, S., Kraynak, A.R., McNamee, J., Nakagawa, Y., Pant, K., Plappert-Helbig, U., Priestley, C., Takasawa, H., Wada, K., Wirnitzer, U., Asano, N., Escobar, P., Lovell, D., Morita, T., Nakajim, M., Ohno, Y., Hayashi, M. (2015) JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results. Mutation Research. 2015 Apr. 29
Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis
April 7, 2015
Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes.Hall JR, Messenger ZJ, Tam HW, Phillips SL, Recio L, Smart RC. Cell Death Dis. 2015 Mar 19
Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice
April 7, 2015
Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan. Recio L, Phillips SL, Maynor T, Waters M , Jackson AF, Yauk CL. Toxicol Sci. 2013 Oct;135(2):369-79.
Comet assay evaluation of six chemicals of known genotoxic potential in rats
April 1, 2015
Hobbs CA L. Recio L, Streicker M, Boyle M , Tanaka J, Shiga A, Witt KL. Genet. Toxicol. Environ. Mutagen. (2015).
Methyl Isobutyl Ketone Exposure-Related Increases in Specific Measures of Nephropathy in Male Rats
April 1, 2015
Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. Toxicology. 2015 Mar 19
Gene Expression of Mesothelioma in Vinylidene Chloride-exposed F344/N Rats Reveal Immune Dysfunction
February 20, 2015
Blackshear PE1, Pandiri AR2, Nagai H3, Bhusari S3, Hong HH3, Ton TV3, Clayton NP3, Wyde M4, Shockley KR5, Peddada SD5, Gerrish KE6, Sills RC3, Hoenerhoff MJ7. Toxicol Pathol. 2014 Jun 23
Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability
January 20, 2015
Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer NC, Andrade CH, Tropsha A. (2015) Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization. Toxicology and Applied Pharmacology,
Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization
January 20, 2015
Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer NC, Andrade CH, Tropsha A. (2015) Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds. Toxicology and Applied Pharmacology,
t4 workshop report: Integrated Testing Strategies (ITS) for Safety Assessment ALTEX
December 5, 2014
Rovida C, Alépée N, Api AM, Basketter DA, Bois FY, Caloni F, Corsini E, Daneshian M, Eskes C, Ezendam J, Fuchs H, Hayden P, Hegele-Hartung C, Hoffmann S, Hubesch B, Jacobs MN, Jaworska J, Kleensang A, Kleinstreuer N, Lalko J, Landsiedel R, Lebreux F, Luechtefeld T, Locatelli M, Mehling A, Natsch A, Pitchford JW, Prater D, Prieto P, Schepky A, Schuurmann G, Smirnova L, Toole C, van Vliet E, Weisensee D, Hartung T. 2014. t4 workshop report: Integrated Testing Strategies (ITS) for Safety Assessment ALTEX (in press).
Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity
December 5, 2014
Chang X, Kleinstreuer N, Ceger P, Hsieh J-H, Allen D, Casey W. Application of reverse dosimetry to compare in vitro and in vivo estrogen receptor activity. Applied In Vitro Toxicology (in press).
Immediate and long-term consequences of vascular toxicity during zebrafish development
December 5, 2014
Tal TL, McCollum CW, Harris PS, Olin J, Kleinstreuer N, Wood CE, Hans C, Shah S, Merchant FA, Bondesson M, Knudsen TB, Padilla S, Hemmer MJ. 2014. Immediate and long-term consequences of vascular toxicity during zebrafish development. Reprod Toxicol 48:51–61.
Open source software implementation of an integrated testing strategy for skin sensitization potency
December 5, 2014
Pirone JR, Smith M, Kleinstreuer NC, Burns TA, Strickland J, Dancik Y, Morris R, Rinckel LA, Casey W, Jaworska JA. 2014. Open source software implementation of an integrated testing strategy for skin sensitization potency based on a Bayesian network. ALTEX 31: 336–340.
Comments how to make the new vision of toxicity testing in the 21st century a reality
December 5, 2014
McKim A, Goldberg A, Kleinstreuer N, Busquet F, Andersen M. 2014. Roundtable discussion: Comments on how to make the new vision of toxicity testing in the 21st century a reality. Applied In Vitro Toxicology 1(1): 5–10.
t4 workshop report: Lessons Learned, Challenges, and Opportunities: The U.S. EDSP
December 5, 2014
Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG, Willett CE, Andersen ME, Borgert CJ, Coady KK, Dourson ML, Fowle JR, Gray LE, Lamb JC, Ortego LS, Schug TT, Toole CM, Zorrilla LM, Kroner OL, Patterson J, Rinckel LA, Jones BR. 2014. t4 workshop report: Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program. ALTEX 31:63-78.
Report on the International Workshop on Alternatives to the Murine Histamine Sensitization Test
December 5, 2014
Isbrucker R, Arciniega J, McFarland R, Chapsal J-M, Xing D, Bache C, Nelson S, Costanzo A, Hoonakker M, Castiaux A, Halder M, Casey W, Johnson N, Jones B, Doelling V, Sprankle C, Rinckel L, Stokes W. 2014. Report on the International Workshop on Alternatives to the Murine Histamine Sensitization Test (HIST) for Acellular Pertussis Vaccines: State of the Science and the Path Forward. Biologicals 42(2):114-122.
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor
December 5, 2014
Huang R, Sakamuru S, Martin MT, Reif DM, Judson RS, Houck KA, Casey W, Hsieh J-H, Shockley KR, Ceger P, Fostel J, Witt KL, Tong W, Rotroff DM, Zhao T, Shinn P, Simeonov A, Dix DJ, Austin CP, Kavlock RJ, Tice RR, Xia M. 2014. Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. Nature Scientific Reports
Quantitative profiling of environmental chemicals and drugs that modulate farnesoid X receptor
November 5, 2014
Hsu CW, Zhao J, Huang R, Hsieh J-H, Hamm J, Chang X, Houck K, M Xia. 2014. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Nature Scientific Reports
Case study on the utility of hepatic gene expression profiling in the risk assessment of furan.
October 15, 2014
Jackson AF, Williams A, Recio L, Waters MD, Lambert IB, Yauk CL. 2014. Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. Toxicol Appl Pharmacol. 274(1):63-77.
Cytotoxicity of naphthalene toward cells from target and non-target organs in vitro.
October 15, 2014
Kedderis GL, Shepard KG, Recio. L. 2014. Cytotoxicity of naphthalene toward cells from target and non-target organs in vitro. Chem Biol Interact. 209:85-95.
Relative potency for altered humoral immunity induced by polybrominated & polychlorinated dioxins.
October 15, 2014
Frawley R, DeVito M, Walker NJ, Birnbaum L, White K Jr, Smith M, Maynor T, Recio L, Germolec D. 2014. Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. Toxicol Sci. 139(2):488-500.
BrdU treatment to measure hepatocellular proliferation does not mask furan-induced mRNA changes.
October 15, 2014
Webster AF, Williams A, Recio L, Yauk CL. 2014. Bromodeoxyuridine (BrdU) treatment to measure hepatocellular proliferation does not mask furan-induced gene expression changes in mouse liver. Toxicology. 323C:26-31.
Performance standards and alternative assays: practical insights from skin sensitization.
August 28, 2013
Kolle SN, Basketter DA, Casati S, Stokes WS, Strickland J, van Ravenzwaay B, Vohr HW, and Landsiedel R. 2013. Performance standards and alternative assays: Practical insights from skin sensitization. Regul Toxicol Pharmacol 65: 278-85.
A computational model predicting disruption of blood vessel development.
August 28, 2013
Kleinstreuer N, Dix D, Rountree M, Baker N, Sipes N, Reif D, Spencer R, Knudsen T. (2013) A Computational Model Predicting Disruption of Blood Vessel Development. PLoS Comput Biol 9(4): e1002996.
Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course
June 3, 2013
Boyle MC, Boyle MH, and the Sixth Rodent Pathology Course Committee. 2013. Meeting Report: Urinary Pathology; Sixth Research Triangle Park Rodent Pathology Course. Vet. Pathol. 50(3): 563-8.
Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform.
April 29, 2013
Jackson AF, Williams A, Moffat I, Phillips SL, Recio L, Waters MD, Lambert IB, Yauk CL. 2013. Preparation of archival formalin-fixed paraffin-embedded mouse liver samples for use with the Agilent gene expression microarray platform. J Pharmacol Toxicol Methods. S1056-8719(13)00211-6.
Biomarkers of Exposure and Effect in Human Lymphoblastoid TK6 Cells Following [13C2]-Acetaldehyde Ex
April 29, 2013
Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, and Swenberg JA. 2013. Biomarkers of Exposure and Effect in Human Lymphoblastoid TK6 Cells Following [13C2]-Acetaldehyde Exposure. Toxicol Sci. 133(1): 1-12. Editor’s Highlight
A C. elegans Screening Platform for the Rapid Assessment of Chemical Disruption of Germline Function
April 28, 2013
Allard P, Kleinstreuer N, Knudsen T, Colaiacovo M. (2013) A novel chemical screening strategy for assessing environmental germline disruption in C. Elegans. Env Health Persp doi:10.1289/ehp.1206301.
Proceedings of the 2012 National Toxicology Program Satellite Symposium.
April 9, 2013
Elmore S.A., Berridge, B. R., Boyle, M.C., Cora, M.C., Hoenerhoff, M.J., Kooistra, L., Laast, V.A., Morrison, J.P., Rao, D.,Rinke, M. and Yoshizawa, K. 2013. Proceedings of the 2012 National Toxicology Program Satellite Symposium. Toxicol Pathol. 41: 151-180.
Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders:
April 9, 2013
Behl, M., Rao, D., Aagaard, K., Davidson, T.L., Levin, E.D., Slotkin, T.A., Srinivasan, S., Wallinga, D., White, M.F., Walker,V.R., Thayer, K.A., Holloway, A.C. 2013. Evaluation of the Association between Maternal Smoking, Childhood Obesity, and Metabolic Disorders: A National Toxicology Program Workshop Review. Environ Health Perspect. 121(2): 170-180.
Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghatti
December 12, 2012
Maronpot, R., Davis, J., Moser, G., Giri, D., Hayashi, S. 2012. Evaluation of 90-day oral rat toxicity studies on the food additive, gum ghatti. Food and Chemical Toxicology, 51: 215-224.
Report on the International Workshop on Alternative Methods for Human & Veterinary Rabies Vaccines
August 14, 2012
Stokes W, McFarland R, Kulpa-Eddy J, Gatewood D, Levis R, Halder M, Pulle G, Kojima H, Casey W, Gaydamaka A, Miller T, Brown K, Lewis C, Chapsal, Bruckner L, Gairola S, Kamphuis E, Rupprecht CE, Wunderli P, McElhinney L, De Mattia F, Gamoh K, Hill R, Reed D, Doelling V, Johnson N, Allen D, Rinckel L, and Jones B. 2012. Report on the International Workshop on Alternative Methods for Human and Veterinary Rabies Vaccine Testing: State of the Science and Planning the Way Forward. Biologicals.
Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in mouse
July 19, 2012
Burns, KA, Rodriguez, KF, Hewitt, SC, Janardhan, KS, Young, SL, Korach, KS. Role of Estrogen Receptor Signaling Required for Endometriosis-like lesion Establishment in a mouse model. Endocrinology Epub June 14 2012.
Proliferative and Non-proliferative Lesions of the Rat and Mouse Central & Peripheral Nervous System
July 19, 2012
Kaufmann,W., Bolon, B., Bradley, A., Butt, M., Czasch, S., Garman, R.H., George, C., Groters S., Krinke, G., Little, P., McKay, J., Narama, I., Rao, D., Shibutani, M., and Sills, R.A. (2012) Proliferative and Non-proliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems. Toxicol Pathol.40: 87S-157S.
Proceedings of the 2011 National Toxicology Program Satellite Symposium
July 19, 2012
Boorman,G., Crabbs, T.A., Kolenda-Roberts, H., Latimer, K., Miller, a.D., Muravnick, K.B., Nyska, A., Ochoa, r., Pardo, I.d., Ramot, Y., Rao, D.B., Schuh, J., Suttie, A., Travlos, G.S., Ward, J.M., Wolf, J.C., and Elmore, S.A. Proceedings of the 2011 National Toxicology Program Satellite Symposium. Toxicol Pathol. (2012) 40: 321-344.
Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors
July 19, 2012
Morgan DL, Jokinen MP, Price HC, Gwinn WM, Palmer SM, Flake GP. Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: Implication for bronchiolitis obliterans in humans. Toxicol. Pathol. 40:448-465, 2012.
Morphologic aspects of rodent cardiotoxicity in a restrospective evaluation of National Toxicology P
July 19, 2012
Jokinen MP, Lieuallen WG, Boyle MC, Johnson CL, Malarkey DE, Nyska A. Morphologic aspects of rodent cardiotoxicity in a restrospective evaluation of National Toxicology Program studies. Toxicol. Pathol. 39:850-860, 2011.
Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol
July 19, 2012
Michael C. Boyle, Torrie A. Crabbs, Michael E. Wyde, J. Todd Painter, Georgette D. Hill, David E. Malarkey, Warren G. Lieuallen, and Abraham Nyska(2012) Intestinal Lymphangiectasis and Lipidosis in Rats Following Subchronic Exposure to Indole-3-Carbinol via Oral Gavage. Toxicologic Pathology, Vol. 40, No. 4, 561–576 (2012).
Comparison Comet Assay Dose-Response Ethyl Methanesulfonate Freshly Prepared Vs Cryoprepared Tissues
July 18, 2012
Recio, L., Kissling, G.E., Hobbs, C.A., and Witt, K.L. (2012) Comparison of Comet Assay Dose-Response for Ethyl Methanesulfonate Using Freshly Prepared Versus Cryopreserved Tissues. Environmental and Molecular Mutagenesis 53, 101-113. DOI: 10.1002/em.20694.
Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti
June 18, 2012
Hobbs, C.A., Swartz, C., Maronpot, R., Davis, J., Recio, L., and Hayashi, S. (2012) Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti. Food and Chemical Toxicology 50, 854-860. DOI: 10.1016/j.fct.2011.11.021.
Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats
June 18, 2012
Hobbs, C.A., Chhabra, R.S., Recio, L., Streicker, M. and Witt, K.L. (2012) Genotoxicity of Styrene-Acrylonitrile Trimer in Brain, Liver, and Blood Cells of Weanling F344 Rats. Environmental and Molecular Mutagenesis 53, 227-238. DOI: 10.1002/em.21680
Assessment of Naphthalene-Induced Genotoxicity & Gluathione Detoxication in Human TK6 Lymphoblasts
March 26, 2012
Recio L, Shepard KG, Hernandez, LG, Kedderis GL. 2012. Dose-Response Assessment of Naphthalene-Induced Genotoxicity and Glutahione Detoxication in Human TK6 Lymphoblasts. Toxicol. Sci. 126(2):405-412.
Therapeutic Ultrasound as a Potential Male Contraceptive
March 23, 2012
Tsuruta JK, Dayton PA, Gallippi CM, O’Rand MG, Streicker MA, Gessner, RC, Gregory TS, Silva E JR, Hamil, KG, Moser GJ, Sokai, DC. 2012. Therapeutic Ultrasound as a Potential Male Contraceptive: Power, Frequency and Temperature Required to Deplete Rat Testes of Meiotic Cells and Epididymides of Sperm Determined Using Commercially Available System. Reproductive Biology and Endocrinology 10:7.
15-Day Intact Male Rat Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical
March 23, 2012
Becker RA, Bergfelt, DR, Borghoff S, Davis JP, Hamby BT, O’Connor JC, Kaplan AM, Sloan CS, Tyl, RW, Wade M, Marty MS. 2012. Interlaboratory Study Comparison of the 15-Day Intact Adult Male Rat Screening Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical. Birth Defects Research (Part B). (95):63-78.
Improving Animal Welfare and Reducing Animal Use for Veterinary Vaccine Potency Testing
January 23, 2012
Stokes WS, Brown K, Kulpa-Eddy J, Srinivas G, Halder M, Draayer H, Galvin J, Claasen I, Gifford G, Woodland R, Doelling V, Jones B. 2011. Improving Animal Welfare and Reducing Animal Use for Veterinary Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):84-105.
Alt. Methods to Reduce, Refine & Replace Animal Use for Veterinary Vaccine Post-Licensing Testing
January 13, 2012
Kulpa-Eddy J, Srinivas G, Halder M, Brown K, Draayer H, Glavin J, Claassen I, Gifford G, Woodland R, Doelling V, Jones, B, Stokes WS. 2011. Alternative Methods and Strategices to Reduce, Refine and Replace Animal Use for Veterinary Vaccine Post-Licensing Safety Testing: State of the The Science and Future Directions.Procedia in Vaccinology(5):106-119.
Alternative Methods to Reduce, Refine & Replace Animal Use for Human Vaccine Post-Licensing Testing
January 13, 2012
Isbrucker R, Levis R, Casey W, McFarland R, Schmitt M, Arciniega J, Descamps J, Finn T, Hendriksen C, Horiuchi Y, Keller J, Kojima H, Sesardic D, Stickings P, Johnson NW, Allen D. 2011. Alternative Methods and Strategies to Reduce, Refine and Replace Animal Use for Human Vaccine Post-Licensing Safety Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):47-59.
Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing
January 13, 2012
Kulp-Eddy J, Srinivas G, Halder M, Hill R, Brown K, Roth J, Draayer H, Galvin G, Woodland R, Doelling V, Jones B, Stokes WS. 2011. Non-Animal Replacement Methods for Veterinary Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):60-83.
Improving Animal Welfare and Reducing Animal Use for Human Vaccine Potency Testing
January 13, 2012
Casey W, Schmitt M, McFarland R, Isbrucker R, Levis R, Arciniega J, Descamps J, Finn T, Hendriksen C, Horluchi Y, Keller, J, Kojima H, Sesardic D, Stickings P, Johnson NW, Lipscomb E, Allen D. 2011. Improving Animal Welfare Reducing Animal Use for Human Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5):33-46.
Non-Animal Replacement Methods for Human Potency Testing: State of the Science and Future Directions
January 13, 2012
McFarland R, Verthelyi D, Casey W, Arciniega J, Isbrucker R, Schmitt M, Finn T, Descamps J, Horiuchi Y, Sesardic D, Stickings P, Johnson NW, Lipscomb E, Allen D. 2011. Non-Animal Replacement Methods for Human Vaccine Potency Testing: State of the Science and Future Directions. Procedia in Vaccinology(5): 16-32.
Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti
December 21, 2011
Hobbs CA, Swartz C, Maronpot R, Davis J, Recio L, and Hayashi S. 2011. Evaluation of the Genotoxicity of the Food Additive, Gum Ghatti. Food and Chemical Toxicology DOI:10.1016/j.fct.2011.11.021.
Improvement of In Vivo Genotoxicity: Acute Tests and Integration into Standard Toxicity Testing
November 26, 2011
Rothfuss A, Honma M, Czich A, Aardema MJ, Burlinson B, Galloway S, Hamada S, Kirkland D, Heflich RH, Howe J, Nakajima M, O’Donovan M, Plappert-Helbig U, Priestley C, Recio L, Schuler M, Uno Y, and Martus HJ. 2011. Improvement of In Vivo Genotoxicity: Combination of Acute Tests and Integration into Standard Toxicity Testing. Mutat. Res. 723: 108-120.
Comet Assay Dose-Response for Ethyl Methanesulfonate Using Freshly Prepared Vs. Cryopreserved Tissue
November 26, 2011
Recio L, Kissling GE, Hobbs CA, and Witt KL, 2011. Comparison of Comet Assay Dose-Response for Ethyl Methansulfonate Using Freshly Prepared Versus Cryopreserved Tissues. Environmental and Molecular Mutagenesis (in press).
Using Fewer Animals to Identify Chemical Eye Hazards: Criteria to Maintain Hazard Classification
October 20, 2011
Haseman JK,Allen DG,Lipscomb EA,Truax JF,Stokes WS. 2011. Using Fewer Animals to Identify Chemical Eye Hazards: Revised Criteria Necessary to Maintain Equivalent Hazard Classification. Regulatory Toxicology and Pharmacology 61:98-104.
Disseminiated Histoplasmosis with Concurrent Oral Candidiasis in an Eclectus Parrot
October 19, 2011
Quist EM,Belcher C,Levine G,Johnson M,Heatley JJ,Kiupel M, Giri D. 2011. Disseminated Histoplasmosis with Concurrent Oral Candidiasis in an Electus Parrot (Eclectus Roratus). Avian Pathol. 40(3):339.
Cerebral and Renal Phaeohyphomycosis in a Dog Infected with Bipolaris Species
October 19, 2011
Giri DK,Sims WP,Sura R,Cooper JJ,Gavrilov BK,Mansell J. 2011. Cerebral and Renal Phaeohhyphomycosis in a Dog Infected with Bipolaris Species. Vet Pathol. 48(3):754-7.
Neoplastic and Nonneoplastic Liver Lesions Induced by Dimethylnitrosamine in Japanese Medaka Fish
October 17, 2011
Hobbie KR,DeAngelo AB,George MH,Law JM. 2011. Neoplastic and Nonneoplastic Liver Lesion Induced by Dimethylnitrosamine in Japanes Medaka Fish. Vet. Pathol. Online. DOI: 10.1177/0300985811409443.
Liver Toxicity and Carcinogenicity in f344/n Rats and b6cf1 Mice Exposed to Kava Kava
September 22, 2011
Behl M,Nyska A,Chhabra RS,Travlos G,Fomby LM,Sparrow BR,Hejtmancik MR,Chan PC. 2011. Liver Toxicity and Carcinogenicity in f344/n Rats and b6c3f1 Mice Exposed to Kava Kava. Food and Chemical Toxicology. In press for publication in November 2011.
Safety Assessment of Allergic Contact Dermatitis Hazards: An Analysis Supporting Reduced Animal Use
September 22, 2011
Haseman JK,Strickland J,Allen D,Salicru E,Paris M,Tice RR,Stokes WS. 2011. Safety Assessment of Allergic Contact Dermatitis Hazards: An Analysis Supporting Reduced Animal Use for the Murine Local Lymph Node Assay. Regulatory Toxicology and Pharmacology 59: 191-96.
Assessment of a Regulated AAV2 Gene Transfer Vector After Murine Submandibular Glands Delivery
September 21, 2011
Zheng C,Voutetakis A,Goldstein B,Afione S,Rivera V,Clackson T,Wenk M,Boyle M,Nyska A,Chiorini J,Vallant M,Irwin R,Baum B. 2011. Assessment of the Safety and Biodistribution of a Regulated AAV2 Gene Transfer Vector After Delivery to Murine Submandibular Glands. Toxicological Sciences.
Effects of Atrazine on Steroidgenesis in Rat Granulosa and H295R Adrenal Cortical Carcinoma Cells
September 20, 2011
Tinfo NS,Hotchkiss MG,Buckalew AR,Zorrilla LM,Cooper RL,Laws SC. 2011. Understanding the Effects of Atrazine on Steriodogenesis in Rat Granulosa and H295 Adrenal Cortical Carcinoma Cells.Reprod. Toxicol. 31(2):184-93
Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies
September 18, 2011
Rao, D, Little, PB, Malarkey, D.E, Herbert, RA, Sills, RC. 2011. Histopathological Evaluation of the Nervous System in National Toxicology Program of Rodent Studies: A Modified Approach. Toxicologic Pathology 39: 463-470.
Genetic Toxicology in the 21st Century: Reflections and Future Directions
April 28, 2011
Mahadevan B, Snyder R, Waters M, Benz RD, Kemper RA, Tice RR and Richard AM. 2011. Genetic Toxicology in the 21st Century: Reflections and Future Directions. Environ. Mol. Mutagen. 52.
Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation
March 16, 2011
Hill GD, Moore AB, Kissling GE, Flagler ND, Ney E, Cline JM, Dixon D. 2011. Effects of Hormonally Active Agents on Steroid Hormone Receptor Expression and Cell Proliferation in the Myometrium of Ovariectomized Macaques. Toxicol. Pathol. 39(3): 508-515.
Toxicity Study of Green Tea Extract in Rats and Mice
December 1, 2010
Chan PC, Ramot Y, Malarkey DE, Blackshear P, Kissling GE, Travlos G, Nyska A. 2010. Fourteen week Toxicity Study of Green Tea Extract in Rats and Mice. Toxicol. Pathol. 38(7): 1070-1084.
Characterizing and Predicting Carcinogenicity and Mode of Action
April 24, 2010
Waters M, Jackson MA, and Lea IA. 2010. Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods. Mutat Res 705: 184-200.
Dose-Response of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay
April 1, 2010
Recio L, Hobbs CA, Caspary W, Witt KL. 2010. Dose-Response Assessment of Four Genotoxic Chemicals in a Combined Mouse and Rat Micronucleus and Comet Assay Protocol. Toxicol Sciences 35(2): 149-162.
No Biomarkers of Genetic Damage or Pathological Changes in Male Rats Administered Ritalin
January 1, 2010
Witt KL, Malarkey DE, Hobbs CA, Davis JP, Kissling GE, Caspary W, Travlos G, Recio L. 2010. No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days. Environ Mol Mutagen 51(1): 80-88.