Opportunity
Evaluate Tox21 and/or ToxCast high-throughput screening data for food-use chemicals using computational toxicology methods and in-house expertise.
Clearly communicate data and analyses in reports and presentations.
Identify, highlight, analyze and explain the most important findings from within a broad data set.
Challenges:
Identify and develop methods optimized to address project goals.
Establish strong project management foundation and communication channels meeting client expectations and allowing client to provide ongoing feedback.
Integrate data releases on an ongoing basis to account for updates of source databases; adjust methods and processes as needed.
Outcomes:
Developed novel methods, drawing on extensive computational expertise and strong fundamental knowledge of toxicology and biochemistry, to integrate cheminformatics with large-scale biochemical in vitro data.
Created a unique workflow to account for continual updating of source databases throughout the course of the study.
Ensured flexibility in workflow to integrate client feedback, follow up on suggestions and investigate novel methodology.
Maintained clear and open lines of communication through reports and web conferences to keep all parties up to date and address specific client requirements.
Provided materials that enabled the client to make this complex work approachable and understandable at nearly a dozen international meetings (posters and presentations) and through two peer-reviewed journal articles.
